ADAM33基因与慢性阻塞性肺疾病易感性的Meta分析

Polymorphisms of the ADAM 33 gene and chronic obstructive pulmonary disease risk:a meta-analysis

目的通过Meta分析ADAM33基因T1(rs2280091),S1(rs3918396)和S2(rs528557)位点与慢性阻塞性肺病的易感性之间的关系。方法收集Pubmed数据库,Embase数据库,中国国家知识基础设施数据库(CNKI)和万方数据库中2017年9月5日之前发表的有关ADAM33基因多态性与慢性阻塞性肺病的易感性之间关联的文献,两个独立工作人员仔细的评估所有的研究,明确复合纳入标准的文献,提取每项研究中的下列信息:第一作者的姓名,出版年份,种族,病例和对照数,慢性阻塞性肺病的定义,病例组和对照组的基因型分布,使用METAGEN(STATA12.0)和Revman5.0软件进行统计分析。结果 Meta分析共纳入10项病例对照研究,其中包括慢性阻塞性肺疾病患者2139例和健康对照组3765例。结果表明:S2(rs528557)和T1(rs2280091)并没有增加或降低慢性阻塞性肺病的易感性。S1(rs3918396)(GG+AG vs. AA)与亚洲人群慢性阻塞性肺病易感性显著相关:ORtotal=1.27 [95%confidence interval(CI)1.03 1.56,P=0.03],ORAsian=1.44(95%CI 1.13 1.83,P=0.003)。结论通过对数据库中与COPD及ADAM33相关的研究进行Meta分析,研究了ADAM33和慢性阻塞性肺病的易感性之间的关联。研究人员的研究结果表明:S2(rs528557),T1(rs2280091)纯合子携带者并没有增加或减少慢性阻塞性肺病的风险;在亚洲人群S1(rs3918396)(GG+AG vs. AA)与慢性阻塞性肺病显著相关。

Objective Meta-analysis was used to analyze the relationship between ADAM33 gene T1(rs2280091), Sl(rs3918396)and S2(rs528557) loci with chronic obstructive pulmonary disease susceptibility. Methods The literature published before September5, 2017 on the association between ADAM33 gene polymorphism and the susceptibility to chronic obstructive pulmonary disease(COPD)were collected from the Pubmed database, the Embase database, the China National knowledge Infrastructure Database(CNKI) and the Wanfang Database, Two independent staff carefully evaluated all the studies, clearly combined the standard literature, extracted the following information from each study: the first author name, year of publication, race, case and control, The definition of chronic obstructive pulmonary disease(COPD) and genotype distribution in case group and control group were analyzed by METAGEN(STATA12.0) and Revman5.0 software. Results Through the literature contained in the 10 and 3765 in 2139 COPD control group, the results showed that S2(rs528557) and T1(rs2280091) did not increase or decrease the risk of chronic obstructive pulmonary disease. In terms of race stratification, Sl(rs3918396)(GG + AG vs. AA) in Asian populations had associated with susceptibility to COPD. ORtotal was 1.27(95% CI 1.03-1.56, P= 0.03), ORAsian was 1.44(95% CI 1.13-1.83, P = 0.003). Conclusion The association between ADAM33 and susceptibility to chronic obstructive pulmonary disease(COPD) was studied by Meta analysis of COPD and ADAM33 related studies in the database. Our results showed that S2(rs528557), T1(rs2280091) homozygous carriers did not increase or decrease the risk of chronic obstructive pulmonary disease(COPD),and in Asian population Sl(rs3918396)(GG AG vs. AA) was significantly associated with COPD.