GnRHa联合子宫腺肌症病灶剔除术治疗子宫腺肌症的临床效果观察

Clinical observation of GnRHa combined with adenomyosis in the treatment of adenomyosis

目的观察促性腺激素释放素激动剂(GnRHa)联合子宫腺肌症病灶剔除术在子宫腺肌症治疗中的应用效果。方法选择2014年1月-2017年6月期间于本院行子宫腺肌症病灶剔除术的患者100例,按随机数字表法分为两组,各50例。两组均于腹腔镜下或开腹行子宫腺肌症病灶剔除术,观察组在术后给予GnRHa治疗。对比两组临床疗效及治疗前、用药结束2个月后的子宫体积、月经量及痛经程度,术后进行为期12个月的随访观察两组患者的复发情况。结果两组治疗前子宫体积、月经量及痛经程度对比,差异无统计学意义(P>0.05);观察组治疗后子宫体积、月经量小于对照组,痛经程度评分低于对照组,差异有统计学意义(P<0.05);观察组临床总有效率高于对照组,复发率低于对照组,差异有统计学意义(P<0.05)。结论GnR Ha联合子宫腺肌症病灶剔除术治疗子宫腺肌症效果显著,能够有效降低复发风险,利于预后。

Objective To observe the effect of gonadotropin-releasing hormone agonist(GnRHa) combined with adenomyosis in the treatment of adenomyosis. Methods A total of 100 patients who underwent adenomyosis in our hospital from January 2014 to June 2017 were enrolled. The patients were divided into two groups according to the random number table, with 50 cases in each group. Both groups underwent laparoscopic or open abdomen ablation of the adenomyosis, and the observation group received GnRHa treatment after surgery.The clinical efficacy of the two groups and the uterine volume, menstrual volume and degree of dysmenorrhea before and after 2 months at the end of the treatment were compared. The recurrence of the two groups was observed after 12 months of follow-up. Results There was no significant difference in uterine volume, menstrual volume and dysmenorrhea between two groups(P > 0.05). The uterus volume and menstrual volume in the observation group were lower than those in the control group, and the dysmenorrhea degree score was lower than that in the control group. The significance of learning(P<0.05);the total effective rate of the observation group was higher than that of the control group, and the recurrence rate was lower than that of the control group, the difference was statistically significant(P < 0.05).Conclusion GnRHa combined with adenomyosis has a significant effect on adenomyosis, which can effectively reduce the risk of recurrence and prognosis.