中西医结合治疗慢性阻塞性肺疾病合并肺部感染的临床疗效观察

Clinical study on chronic obstructive pulmonary disease complicated with pulmonary infection treated with integrated traditional Chinese and Western Medicine

目的研究观察中西医结合治疗慢性阻塞性肺疾病合并肺部感染的临床应用效果。方法选择2016年1月-2017年1月期间本院收治的慢性阻塞性肺疾病合并肺部感染患者120例为研究对象,按随机数字表法分为观察组(n=60)和对照组(n=60)。对照组采用常规的西医治疗,观察组患者在此基础上增加中药清肺化痰汤治疗。对两组患者治疗效果、肺功能及炎症因子水平进行综合评价比较。结果①观察组临床总有效率为91.67%(55/60),对照组为78.33%(47/60),组间比较差异有统计学意义(P <0.05)。②治疗前两组患者的肺功能各项指标比较无统计学差异性,治疗后观察组患者的第1s用力呼气容积(FEV1)、肺活量(FVC)、FEV1/FVC比值、血氧饱和度(SpO2)均高于对照组患者,组间比较差异有统计学意义(P <0.05)。③观察组患者炎症因子包括C反应蛋白(CRP)、白介素-6(IL-6)、血清转化生长因子-β(TGF-β)均低于对照组患者,组间比较差异有统计学意义(P <0.05)。结论采用中西医结合的方式治疗慢性阻塞性肺疾病合并肺部感染的临床疗效显著,改善患者的临床症状和肺功能,改善患者的炎症因子水平,有较高的临床应用价值并加以推广应用。

Objective To study the clinical effect of integrated traditional Chinese and western medicine in the treatment of chronic obstructive pulmonary disease complicated with pulmonary infection. Methods 120 patients with chronic obstructive pulmonary disease complicated with pulmonary infection in our hospital from January 2016 to January 2017 were selected as the research objects. They were divided into the observation group(n = 60) and the control group(n = 60) by random number table method. The control group was treated with conventional western medicine, and the observation group was treated with Qingfei Huatan Decoction on the basis of this treatment.The therapeutic effects, pulmonary function and inflammatory factors were compared and evaluated between the two groups. Results The total effective rate was 91.67%(55/60) in the observation group and 78.33%(47/60) in the control group. The lung function indexes before treatment were compared between the two groups no significant difference were observed 1 s,forced expiratory volume groups after treatment(FEV1),vital capacity(F VC),FEV1/FVC ratio, oxygen saturation(Sp02) were higher than that of the control group. The inflammatory factors including C reactive protein(CRP), interleukin-6(IL-6) and serum transforming growth factor beta(TGF-beta) in the observation group were lower than that of the control group. Conclusion The combination of traditional Chinese and western medicine treatment of chronic obstructive pulmonary disease with pulmonary infection clinical curative effect is remarkable, it improves the patient’s clinical symptoms and pulmonary function, also improves the level of inflammatory factors in patients with high clinical value,which should promote for popularization and application.