莫西沙星与左氧氟沙星序贯治疗老年社区获得性肺炎的临床观察

Clinical study on sequential therapy of moxifloxacin and levofloxacin in elderly patients with community-acquired pneumonial

目的分析在老年社区获得性肺炎中应用莫西沙星与左氧氟沙星序贯治疗的临床价值,对比二者效果。方法依照乱数表法随机抽取本院2015年1月-2018年2月所收老年社区获得性肺炎患者120例进行对比研究,60例对照组患者采取左氧氟沙星治疗,另60例实验组患者则采用莫西沙星治疗,对比二者治疗效果。结果实验组患者静脉治疗时长和其总抗感染治疗时长均明显低于对照组患者(差异均有P <0.05);实验组患者治疗后临床总有效率为95.0%,相较对照组(86.7%)无显著差异(P> 0.05),但前者治疗后痊愈率(78.3%)明显高于后者(61.7%)(P <0.05);实验组治疗后细菌根除率(97.3%)显著优于对照组患者(71.1%)(P <0.05)。结论在老年社区获得性肺炎中应用莫西沙星与左氧氟沙星序贯治疗均可取得一定疗效,二者临床总有效率无显著差别;相较左氧氟沙星而言,莫西沙星治疗时长更短、痊愈率和细菌根除率更高。

Objective The clinical value of sequential therapy with moxifloxacin and levofloxacin in elderly community acquired pneumonia was analyzed and their effects were compared.Methods According to the random number table method,120 elderly patients with community-acquired pneumonia admitted by our hospital from January 2015 to February 2018 were randomly selected for comparative study.60 patients in the control group were treated with levofloxacin,and 60 patients in the experimental group were treated with moxifloxacin,and the therapeutic effects of the two groups were compared.Results The duration of intravenous treatment and the duration of total anti-infective treatment in the experimental group was significantly lower than that in the control group(P<0.05).After treatment,the total effective rate of the treatment group was 95.0%,compared with that in the control group(86.7%).There was no significant difference(P>0.05).but the recovery rate(78.3%)was significantly higher than that of the latter(61.7%)(P<0.05).After treatment,the bacterial eradication rate(97.3%)was significantly better than that of the control group(71.1%)(P<0.05).Conclusion The application of moxifloxacin and levofloxacin sequential therapy in elderly community acquired pneumonia can achieve certain curative effect,and there is no significant difference in the clinical total efficiency between the two groups.Compared to levofloxacin,moxifloxacin has shorter duration,higher cure rate and higher bacterial eradication rate.