节拍化疗对肌层浸润性膀胱癌患者的临床疗效对照研究

Clinical efficacy analysis metronomic chemotherapy for muscle invasive bladder cancer

目的探讨节拍化疗对肌层浸润性膀胱癌患者的临床疗效。方法选择自2013年1月-2015年1月铜川矿务局中心医院泌尿外科就诊的肌层浸润性膀胱癌患者46例,分为对照组及观察组,每组23例,分别接受常规GC方案及节拍化疗,对2组患者临床疗效、肿瘤标志物及VEGF、Ang-1进行检测。结果对照组经化疗后总有效率为47.8%,观察组经化疗后总有效率为73.9%,两组总有效率差异有统计学意义(P<0.05)。对照组及观察组患者化疗后NMP22、CYFR21-1、BTA水平较化疗前显著降低(P<0.05),观察组患者化疗后NMP22、CYFR21-1、BTA水平下降程度较对照组化疗后明显,差异有统计学意义(P<0.05)。对照组及观察组患者化疗后VEGF及Ang-1水平均较化疗前显著下降(P<0.05)。观察组患者化疗后VEGF水平下降程度较对照组明显,差异有统计学意义(P<0.05)。结论节拍化疗可显著提高化疗的临床疗效,该过程可能通过抑制促血管生成相关因子表达来实现。

Objective To investigate the clinical efficacy of metronomic chemotherapy for the patients with bladder cancer infiltrating into muscularis.Methods Enrolled were 46 cases of patients with bladder cancer infiltrating into muscularis from January 2013 to January 2015 who hospitalized in the department of Urinary Surgery in Central Hospital of Tongchuan Mining Bureau.The enrolled cases,totaling 46,were assigned to two groups,that is,control group and observation group,with each 23 cases.the control group was received conventional chemotherapy whereas observational group was given metronomic chemotherapy.The comparison was made of the clinical efficacy,related tumor biomarkers and the level of VEGF and Ang-1between the two assigned groups.Results The total efficacy of control group and observational group were shown to be 47.8% and 73.9%,respectively.There was significantly difference between the two groups(P <0.05);the level of NMP22,CYFR21-1and BTA were observed to be remarkably reduced after chemotherapy both in control group and observational group compared with beforechemotherapy(P <0.05)and In terms of reducing extent,the level of NMP22,CYFR21-1and BTA were found to be significanlty much greater in observational group than that in control group(P <0.05).Additionally,relative to before chemotherapy,both VEGF and Ang-1were shown to be markedly decreased after chemotherapy in control and observational groups(P <0.05);in terms of reducing extent,the level of VEGF and Ang-1were found to be significanlty much greater in observational group than that in control group(P <0.05).Conclusion Metronomic chemotherapy was shown to be capable of significantly improving the clinical efficacy,wherein the related angiogenic factors may be suppressed.