激光辅助孵化对反复种植失败患者解冻周期妊娠结局的影响

The effect of laser assisted hatching on patients with repeated implantation failure in the frozen-thawed cycle

目的探讨激光辅助孵化对反复种植失败患者的解冻周期妊娠结局的影响。方法共纳入85例反复种植失败的患者,其中47例行辅助孵化(辅助孵化组),38例未行辅助孵化(未孵化组)。比较两组患者的临床妊娠率、种植率及活产率等。结果辅助孵化组与未孵化组间妊娠率、种植率差异无统计学意义(P>0.05),但辅助孵化组流产率明显低于未孵化组(22.2%vs 75.0%,P<0.05),而活产率明显高于未孵化组(29.79%%vs5.26%,P<0.05)。结论激光辅助孵化在反复种植失败患者解冻周期中能明显改善其妊娠结局。

Objective To investigate the effects of Laser Assisted Hatching(LAH)patients with repeated implantation failure in frozen-thawed cycles.Methods Enrolled were a total of 85 patients with repeated implantation failure in frozen-thawed cycles,47 were applied by Laser-AH(LAH)while the reminder 38 were non-LAH(NLAH)treated.The clinical pregnancy rate,implantation rate and live delivery rate between the two groups were compared.Results No statistically significant difference was observed of clinical pregnancy rate,implantation rate between LAH group and NLAH group.However,the abortion rate of LAH group was shown to be significant lower than that in NLAH group(22.2% vs 75%,P <0.05)and the live delivery rate of LAH group was observed to be significant higher than that in NLAH group(25.5% vs 5.3%,P <0.05).Conclusion Laser Assisted hatching was shown to be able to significantly improve the outcome of pregnancy for patients with repeated implantation failure in the frozen-thawed cycle.