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线粒体DNA突变和肿瘤发生 被引量：2

Correlation between mutations of mitochondrial DNA and tumorigenesis
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摘要 肿瘤细胞线粒体及线粒体DNA的研究已从形态学改变进展至分子水平的变化。由于近年来在多种肿瘤组织中发现了线粒体DNA的突变 ,而且线粒体DNA的突变率明显高于核基因 ,所以研究者们趋向认为线粒体DNA的突变与肿瘤发生密切相关。我们就近年来线粒体DNA突变与肿瘤关系的研究进展做一综述 。 The research on mitochondrion and mitochondrial DNA in tumor cells has developed from morphological changes to molecular alterations. Because mitochondrial DNA mutations are present in many kinds of tumors and its mutation rate is significantly higher than that of nuclear DNA, researchers have a tendency to think that mitochondrial DNA mutations are closely related to the occurrence of tumor. In this article, we reviewed the development in research on the correlation between mutations of mtDNA and tumorigenesis to investigate the roles of mitochondrial DNA mutations in tumorigenesis.
作者 赵乐 陈葳 李旭
机构地区 西安交通大学第一医院实验医学中心
出处 《国外医学（妇幼保健分册）》 2003年第6期428-430,共3页 Foreign Medical Sciences (Section of Maternal and Child Health)
关键词 线粒体DNA 突变 肿瘤 mitochondrial DNA mutation tumor
分类号 R733 [医药卫生—肿瘤]
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参考文献15

  • 1[1]Chen J Z, Gokden N, Greene G F, et al. Simultaneous generation of multiple mitochondrial DNA mutations in human prostate tumors suggests mitochondrial hyper-mutagenesis[J]. Carcinogenesis,2003,24(9) :1481 - 1487.
  • 2[2]Wong L J, Lueth M, Li X N, et al. Detection of mitochondrial DNA mutations in the tumor and cerebrospinal fluid of medulloblastoma patients[J]. Cancer Res,2003,63(14) :3866 - 3871.
  • 3[3]Liu V W, Shi H H, Cheung A N. et al. High incidence of somatic mitochondrial DNA mutations in human ovarian carcinoma[J]. Cancer Res,2001,61(16) :5998 - 6001.
  • 4[4]Maximo V, Soares P, Seruca R, et al. Microsatellite instability, mitochondrial DNA large deletions, and mitochondrial DNA mutations in gastric carcinoma[J]. Genes Chromosomes Cancer,2001,32(2): 136 - 143.
  • 5[5]Habano W, Nakamura S I, Sugai T, et al. Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: evidence for mismatch repair systems in mitochondrial genome[J].Oncogene, 1998,17(15): 1931 - 1937.
  • 6[6]Tan D J, Chang J, Chen W L. et al. Novel heteroplasmic frameshift and missense somatic mitochondrial DNA mutations in oral cancer of betel quid chewers[ J ]. Genes Chromosomes Cancer,2003,37(2): 186 - 194.
  • 7[7]Parrella P, Seripa D, Matera M G, et al. Mutations of the D310 mitochondrial mononucleotide repeat in primary tumors and cytological specimens [ J ]. Cancer Lett, 2003,190 ( 1 ): 73 -77.
  • 8[8]Tong B C, Ha P K, Dhir K, et al. Mitochondrial DNA alterations in thyroid cancer [ J ]. J Surgical Oncology, 2003,82 (3):170 - 173.
  • 9[9]Maximo V, Soares P, Lima J, et al. Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on Hurthle cell tumors[J]. Am J Pathol, 2002,160(5) :1857- 1865.
  • 10[10]Parella P, Xiao Y, Fliss M, et al. Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates[J]. Cancer Res,2001,61(20) :7623 - 7626.

同被引文献34

  • 1谭端军,刘玲玲,文毅,刘鹏,Julia Chang,Kun-Tu Yeh,Lee Jun C Wong.胞质异质性——人类肿瘤组织线粒体基因突变的普遍现象[J].遗传,2005,27(1):44-48. 被引量：5
  • 2丁忠阳,张峰,蔡兵,俞悦,王学浩,陆飞,孙力.肝癌细胞线粒体DNA D-Loop高变区基因突变的研究及意义[J].实用临床医药杂志,2007,11(3):68-70. 被引量：8
  • 3吴清华,翟心慧.线粒体DNA氧化损伤与肿瘤发生[J].中国病理生理杂志,2007,23(7):1446-1450. 被引量：5
  • 4Kirches E, Krause G, Warich-Kirches M, et al. High frequency of mitochondrial DNA mutations in glioblastoma multiforme identified by direct sequence comparison to blood samples [J]. Int J Cancer, 2001, 93(4) : 534 -538.
  • 5Kirches E, Krause G, Weis S, et al. Comparison between mitochondrial DNA sequences in low grade astrocytomas and corresponding blood samples [J]. Mol Pathol, 2002, 55 (3): 204- 206.
  • 6DeHaan C, Habibi-Nazhad B,Yan E, et al. Mutation in mitochondrial complex Ⅰ ND6 subuuit is associated with defective response to hypoxia in human glioma cells [ J]. Mol Cancer, 2004, 3: 19.
  • 7Ceruti S, Mazzola A, Abbracchio MP. Resistance of human astrocytoma cells to apoptosis induced by mitochondria-damaging agents: possible implications for anticancer therapy [ J ]. Pharmacol Exp Ther, 2005, 314 (2) : 825 - 837.
  • 8Ishikawa K, Takenaqa K, Akimoto M, et al. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis [ J ]. Science, 2008, 320(5876): 661 -664.
  • 9Basso D, Navaqlia F, Foqar P, et al. DNA repair pathways and mitochondrial DNA mutations in gastrointestinal carcinogenesis [ J ]. Clin Chim Acta, 2007, 381(1) : 50 -55.
  • 10Bertagnolli AC, Soares P, Van Ash B, et al. An assessment of the clonality of the components of canine mixed mammary tumors by mitochondrial DNA analysis [ J]. Vet J, 2008 Aug 25. [ Epub ahead of print ].

引证文献2

二级引证文献6

国外医学（妇幼保健分册）
2003年 第6期

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