基质金属蛋白酶及其抑制物与正常及病理妊娠

The relations of matrix metalloproteinase(MMPs) and tissue inhibitor metalloproteinase(TIMPs) with normal and pathologic pregnancies

正常妊娠的顺利进行有赖于滋养层细胞对子宫的适度侵蚀。侵蚀过深过浅均可导致病理妊娠的发生。基质金属蛋白酶及其抑制物是滋养层细胞侵蚀的重要生化介质 ,其与正常及病理妊娠密切相关 。

A successful pregnancy firstly depends on moderate invasion of trophoblast in uterus. Too deep or too shallow invasion may lead to a pathologic pregnancy. Matrix metalloproteinase (MMPs) and tissue inhibitor metalloproteinase (TIMPs) are both important biochemical media for trophoblast invasion, and they are associated closely with normal and pathologic pregnancies. In this article, we summarized progress in relating researches on this topic.