尼莫地平减轻蛛网膜下腔出血后脑损伤

Effect of nimodipine on brain injury secondary to subarachnoid hemorrhage

目的 探讨尼莫地平对蛛网膜下腔出血 (SAH)后脑损伤的防治作用。方法 用血管内穿刺法制作大鼠 SAH模型。对 SAH组和尼莫地平处理组观察 2 4h内局部脑血流量 (r CBF)和脑组织水、电解质含量的动态变化。结果 SAH后 r CBF迅速降低 ,1h达最低值 ,2 4h内持续于低水平状态。 SAH后 6h、2 4h脑组织含水率和 Na+含量明显增加 ,K+含量减低 ;脑组织 Ca2 +含量在 SAH后 1h开始显著增加。尼莫地平对上述的指标均有改善作用。结论 尼莫地平可减轻实验性 SAH后脑损伤。

Objective To investigate the protective effect of nimodipi ne on brain injury secondary to subarachnoid hemorrhage (SAH).Methods Rat SAH models were established by an endovascular perforating method,and d ynamic changes of regional cerebral blood flow (rCBF),brain water and electrolyt es contents were determined in both SAH group and nimodipine treated group.Results In SAH group,rCBF decreased immediately after SAH being produced,and retained at low le vels within 24h. Brain water and sodium contents increased while potassium cont ent decreased at 6h and 24h. Brain calcium content increased significantly from 1h to 24h after induction of SAH. Above alterations in nimodipine treated group were not so obvious as those in SAH group.Concl usion Nimodipine may attenuate brain injury secondary to experimental SAH.