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外周血淋巴细胞CD40/CD40L表达与多发性肌炎/皮肌炎发病关系 被引量：2

The Study of the Function of CD40/CD40L in the Pathogenesis of Polymyositis/Dermatomyositis
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摘要 目的:初步探讨协同刺激分子CD40/CD40L在多发性肌炎(PM)/皮肌炎(DM)发病机制中的作用。方法:采用流式细胞学检测PM/DM患者外周血淋巴细胞CD40、CD40L的表达,并与正常健康人对照。结果:CD40、CD40L在正常健康人外周血淋巴细胞几乎无表达,但在PM/DM患者表达增高,PM患者CD40平均荧光强度为10.24±4.15,CD40L平均荧光强度为1.35±0.77;DM患者CD40平均荧光强度为13.67±5.83,CD40L平均荧光强度为1.73±0.98。PM/DM患者比较差异无显著性(P>0.05)。结论:CD40/CD40L的表达可能参与了PM/DM的发病。 Aim: To primarily probe the function of costimulatory molecules CD40/CD40L in the pathogenesis of PM/DM. Methods: The expression of CD40/CD40L on peripheral blood lymphocytes of PM/DM patients was measured by flow cytometry (FCM) and then compared with that of the healthy people. Results: There was nearly no expression of CD40/CD40L on peripheral blood lymphocytes of healthy people, but their expressions increased in all the 20 PM/DM patients. To PM patients, the average fluorescence intensity (API) of CD40 was 10.24±4.15, and the API of CD40L was 1.35±0.77; while to the DM patients, the API of CD40 was 13.67±5.83, and the API of CD40L was 1.73±0.98. There was no significant difference between PM and DM patients ( P > 0.05). Conclusion:The expression of CD40/CD40L may take part in the pathogenesis of PM and DM.
作者 曾艺 张进 肖波 周文斌 李静 章坚
机构地区 中南大学湘雅医院神经内科
出处 《中国临床神经科学》 2003年第4期335-337,共3页 Chinese Journal of Clinical Neurosciences
基金 国家自然科学基金(39870909) 卫生部科学研究基金(98-2-085)
关键词 外周血 淋巴细胞 CD40/CD40L 多发性肌炎 皮肌炎 发病机制 流式细胞仪 polymyositis dermatomyositis CD40/CD40L flow cytometry
分类号 R593.26 [医药卫生—内科学] R446.1 [医药卫生—诊断学]
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参考文献13

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同被引文献29

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中国临床神经科学
2003年 第4期

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