多形性黄色星形细胞瘤(附21例报告)

Pleomorphic Xanthoastrocytoma (21 Cases Report)

目的:探讨多形性黄色星形细胞瘤(PXA)的临床、病理和治疗效果。方法:回顾分析21例PXA资料。结果:本组肿瘤占神经上皮肿瘤的0.92％,平均年龄27.0岁。临床表现以癫癎和头痛为主,CT、MRI示81.0％的肿瘤位于大脑浅面,66.7％的肿瘤有囊变。病理上肿瘤细胞呈多形性为主,免疫组化CFAP均阳性。术后14例随访4～39个月,全切加放疗复发率12.5％。结论PXA为罕见的胶质瘤类型,好发于青年,肿瘤全切者预后较好,辅以放疗可减少术后复发率。

Aim: To study clinic features, pathology and therapeutic effect of pleomorphic xanthoastrocytoma (PXA). Methods: Retrospective study on 21 patients of PXA.Results:The tumors of our study was abort 0.92% of neuroepithelial tumors.Average age was 27.0 years old.The main clinical manifestations were epilepsy and headsche. CT and MRI revealed 81.0% of tumors occurred in superficial cerebral hemisphere and 66.7% of caes revealed cystic component. Pleomorpliism were observed in most of cases in pathologic studies. Tumors demonstrated immunoreactivity for GFAP (100% of cases) . Follow-up study was done in 14 cases after operation. 12.5% of cases with total resection and radiotherapy had recurrence. Conclusion: PXA was a rare type of astrocytoma. It usually occurred in young subjects. pleomorphic xanthoastroeytoma had a favorable prognosis after total resection. Radiotherapy could reduce the recurrence.