恶性淋巴瘤继发的RS3PE综合征(附一例报告)

RS3PE syndrome secondary to malignant lymphoma:A case report

报告以缓解型血清阴性对称性滑膜炎伴凹陷性水肿(RS3PE)综合征为首发症状的恶性淋巴瘤1例,并复习文献。RS3PE综合征只是一种临床综合征,而非一个独立的疾病,有原发性与继发性之分。继发性RS3PE综合征常与肿瘤、风湿性疾病、血液病等密切相关。其预后与原发疾病密切相关。诊断和治疗时应注意查找其原发疾病。与肿瘤合并出现且随着肿瘤治疗缓解消失的RS3PE综合征称为副瘤性RS3PE综合征。当伴随全身症状与体征、血嗜酸细胞计数和(或)乳酸脱氢酶水平升高时应警惕恶性淋巴瘤。

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a syndrome associated with many conditions, including malignant neoplasms. One case T-cell malignant lymphoma whose first manifestation was RS3PE syndrome is reported, and the related literature is reviewed. RS3PE syndrome can be classified as primary and secondary one. The secondary RS3PE syndrome may not be a specific disease, and its prognosis depends on the primary disorders. The RS3PE syndrome associated with malignant neoplasms is called paraneoplastic RS3PE syndrome. Systemic symptoms and signs, eosinophilia and high lactate dehydrogenase (LDH) may indicate the possible presence of malignant lymphoma.