盐酸利托君联合硝苯地平对先兆流产患者Th17和Treg细胞的影响

Effect of ritodrine hydrochloride combined with nifedipine on the Th17 and Treg cells of patients with threatened abortion

目的研究盐酸利托君联合硝苯地平对先兆流产患者Th17和Treg细胞的影响。方法选取2014年2月至2015年2月海南医学院第二附属医院诊治的90例先兆流产患者作为研究对象。分为对照组和观察组,每组45例。观察组采用盐酸利托君联合硝苯地平进行治疗,对照组采用硫酸镁、葡萄糖注射液进行治疗。观察两组患者治疗前后Th17水平表达、Treg细胞因子水平表达,观察组临床症状消失时间、宫缩消失时间、妊娠延长时间,治疗疗效情况。结果治疗后,观察组IL-17、IL-6(13.29±4.39、11.24±3.40)pg/ml均小于对照组(18.07±5.31、15.47±4.10)pg/ml,差异具有统计学意义(P<0.05);观察组TGF-β1、IL-10(560.83±76.20、176.39±34.58)pg/ml均大于对照组(498.98±72.83、145.28±32.35)pg/ml,差异具有统计学意义(P<0.05);观察组临床症状消失时间(4.50±1.21)d、宫缩消失时间(7.82±2.08)h均小于对照组(7.02±1.98)d、(9.79±3.02)h,妊娠延长时间(39.09±4.93)d大于对照组(29.38±3.20)d,差异具有统计学意义(P<0.05);观察组总有效率95.55%(43/45)优于对照组73.33%(33/45),差异具有统计学意义(P<0.05)。结论盐酸利托君联合硝苯地平能够使先兆流产患者的Th17和Treg细胞达到平衡的状态,有利于妊娠。

Objective To study the effect of ritodrine hydrochloride combined with nifedipine on the Th17 and Treg cellsof patients with threatened abortion.Methods 90 patients with threatened abortion from February 2014 to February 2015 in our hospital were selected and divided into observation group and control group,each of 45 cases.The control group was treated with magnesium sulfate and glucose injection,while the observation group was given ritodrine hydrochloride combined with nifedipine treatment.The expression level of Th17 and Treg cytokinebefore and after treatment were observed in the two groups,and the disappearing time of clinical symptoms and uterinecontraction,the prolonged time of pregnancy and the treatment effect was observed in the observation group.Results After treatment,the levels of IL-17 and IL-6 in the observation group[(13.29±4.39)pg/ml,(11.24±3.40)pg/ml]were lower than those of the control group[(18.07±5.31)pg/ml,(15.47±4.10)pg/ml],with statistically significant differences(P<0.05).The levels of TGF-β1 and IL-10 in the observation group[(560.83±76.20)pg/ml,(176.39±34.58)pg/ml]were higher than those of the control group[(498.98±72.83)pg/ml,(145.28±32.35)pg/ml],with statistically significant differences(P<0.05).The disappearing time of clinical symptoms and uterine contraction in the observation group[(4.50±1.21)d,(7.82±2.08)h]was shorter than that of the control group[(7.02±1.98)d,(9.79±3.02)h],while the prolonged time of pregnancy in the observation group was(39.09±4.93)d,longer than the control group of(29.38±3.20)d,with statistically significant differences(P<0.05).Total effective rate of observation group(95.55%,43/45)washigher than that of the control group(73.33%,33/45),with statistically significant difference(P<0.05).Conclusions Ritodrine hydrochloride combined with nifedipineis conductive to balancing the Th17 and Treg cells in patients with threatened abortion,hereby good for pregnancy.