人类精浆对夫精宫腔内人工授精妊娠结局影响的初步研究

Preliminary study on the effect of human seminal plasma on pregnancy outcome of intrauterine insemination

目的初步研究人类精浆介入夫精宫腔内人工授精(IUI)对妊娠结局的影响。方法选取2016年8月至2016年12月济南军区总医院生殖医学中心的诊治的160例实施夫精宫腔内人工授精助孕的不孕夫妇为研究对象。将其分为两组,盐水注入组和精浆注入组(简称盐水组,精浆组),排除夫精宫腔内人工授精过程中不符合研究要求的病例,最后共有136例入组,盐水注入组75例,精浆注入组61例。前者于超声监测排卵当日用硅橡胶医用导管(作为人工授精管用)于宫颈管内近宫颈外口1cm^2cm处和阴道后穹隆处注入生理盐水,即行夫精宫腔内人工授精,后者于同等时机同等部位注入同等剂量其丈夫精浆,即行夫精宫腔内人工授精。比较两组临床妊娠率。结果精浆注入组的临床妊娠率高于盐水注入组(24.59%和16.00%),两组差异无统计学意义(P=0.21)。结论夫精宫腔内人工授精助孕过程中,精浆有改善妊娠结局的趋势。

Objective To preliminarily study the effect of human seminal plasma on pregnancy outcome of intrauterine insemination(IUI).Methods 160 infertility couples who received IUI in our hospital from August 2016 to December 2016 were selected as research object.They were divided into saline injection group and seminal plasma injection group(referred to as saline groupand seminal plasma group respectively).The cases which didn′t meet the grouping criteria were excluded.There were 75 cases in saline group and 61 cases in seminal plasma group.The saline group received saline injection at 1-2 cm to the external cervix and posterior vaginal fornixunder the ultrasound monitoring at the ovulation day and then received IUI.The seminal plasma group received the same dose of husband seminal plasma at the same location.The clinical pregnancy rate of the two groups was compared.Results The clinical pregnancy rate of seminal plasma group was higher than that of saline group(24.59%and 16.00%),without statistically significant differences between the two groups(P=0.21).Conclusions In the process of IUI,seminal plasma is conductive to improving the outcome of pregnancy.