营养干预对肥胖型多囊卵巢综合症患者抗苗勒管激素和受孕率影响的研究

Effect of nutritional intervention on AMH and conception rate in obese polycystic ovary syndrome patients

目的分析营养干预对肥胖型多囊卵巢综合症患者抗苗勒管激素(anti-miillerian hormone,AMH)和受孕率的影响。方法选择2015年8月至2016年12月枣庄市妇幼保健院诊治的80例肥胖型多囊卵巢综合征不孕患者为研究对象,依照随机信封法将其平均分为观察组和对照组,每组40例患者。观察组患者在对照组基础上联合采用营养干预,对照组患者采用常规方案进行干预。治疗前后分别对两组患者的身体质量指数(body mass index,BMI)、空腹血糖(fasting blood glucose,FBG)和胰岛素抵抗指数(homeostatic model assessment for insulin resistance,HOMA-IR)进行调查,检测患者血清中的AMH水平,并在治疗结束后记录两组患者妊娠率、排卵率和早孕流产率。结果治疗后,两组患者BMI、HOMA-IR和FBG水平均显著降低(P<0.05),且观察组患者BMI、HOMA-IR和FBG水平均显著低于对照组患者(P<0.05)。治疗后,两组患者血中AMH水平均显著降低(P<0.05),且观察组患者血中AMH水平显著低于对照组患者(P<0.05)。治疗后,观察组患者妊娠率和排卵率均显著高于对照组患者(P<0.05),且观察组患者早孕流产率显著低于对照组患者(P<0.05)。结论肥胖型多囊卵巢综合征患者采用营养干预后,可以有效改善患者体内AMH水平并提高患者受孕率。

Objective To analyze the effect of nutritional intervention on anti-miillerian hormone(AMH)and conception rate in obese polycystic ovary syndrome patients.Methods 80 cases of obese polycystic ovary syndrome in Zaozhuang Maternal and Child Health Care Hospital from August 2015 to December 2016 were divided into the observation group and the control group according to the random envelope method,with 40 patients in each group.The control group received routine intervention,while the observation group additionally received combined nutrition intervention.The BMI,FBG,HOMA-IR and AMH level in serum of the two group were investigated before and after the treatment.The pregnancy rate,ovulation rate and early abortion rate of the two groups were recorded after the treatment.Results After the treatment,the levels of BMI,HOMA-IR and FBG of the two groups were significantly decreased(P<0.05),and the levels of BMI,HOMA-IR and FBG of the observation group were significantly lower than those of the control group(P<0.05).The AMH levels in the serum of the two groups were significantly lower(P<0.05)after the treatment,and the AMH level of the observation group was significantly lower than that of the control group(P<0.05).After the treatment,the pregnancy rate and ovulation rate of the observation group were significantly higher than those of the control group(P<0.05),and the abortion rate of early pregnancy of the observation group was significantly lower than that of the control group(P<0.05).Conclusions Nutritional intervention can effectively improve the AMH level and the pregnancy rate of obese polycystic ovary syndrome patients.