卞星青霉素联合多西环素治疗对男性早期梅毒患者皮损、免疫功能及性功能的影响

Effect of benzathine penicillin combined with doxycycline on skin lesions,immune function and sexual function of male patients with early syphilis

目的探究卞星青霉素联合多西环素治疗对男性早期梅毒患者皮损、免疫功能及性功能的影响。方法按纳入与排除标准选取2014年1月至2017年9月武汉市汉阳医院收治的90例男性梅毒患者中作为研究对象。按区化随机化设计分组,对照组41例,给予多西环素治疗,观察组49例则在对照组基础上联合苄星青霉素进行治疗。对比两组皮损范围、皮损严重程度、免疫功能及性功能指标,并统计不良反应发生率。结果治疗后,观察组皮损范围显著缩小,严重指数下降,且皮损范围缩减、严重指数下降幅度均优于对照组;CD3+、CD4+、CD4+/CD8+、NK高于对照组,CD8+低于对照组,差异均具有统计学意义(P<0.05);同时,治疗后两组勃起功能障碍、性欲淡漠及射精障碍患者均下降,性功能正常患者显著上升,但观察组性功能障碍患者显著较对照组多,差异均具有统计学意义(P<0.05),且两组不良反应发生率(14.29%vs 21.95%)对比差异无统计学意义(P﹥0.05)。结论卞星青霉素联合多西环素治疗对男性早期梅毒患者皮损、免疫功能及性功能的改善更显著,且不增加不良反应发生风险。

Objective To explore the effect of benzathine penicillin combined withdoxycycline on the skin lesions,immune function and sexual function of male patients with early syphilis.Methods 90 male patientswith syphilis admitted to the hospital from January 2014 to September 2017 wereselectedand randomly divided intothe control group(41 cases,doxycycline)and the observation group(49 cases,benzathine penicillin combined with doxycycline).The range of skin lesions,severity of skin lesions,immune function and sexual function were compared between the two groups,and the incidence rate of adverse reactions was statistically analyzed.Results After treatment,the range of skin lesions and the severity index decreased significantly in the observation group,more significant than that in the control group.Levels of CD3+,CD4+,CD4+/CD8+and NK were higher while CD8+was lower in the observation group than those in the control group,with statistically significant differences(P<0.05).The proportion of patients with erectile dysfunction,sexual apathy and ejaculatory disorder in the two groups decreased after treatment and that of patients with normal sexual functionincreased significantly,more significant in the observation group than that in the control group with statistically significant difference(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(14.29%vs 21.95%)(P>0.05).Conclusions Benzathine penicillin combined with doxycycline can obviously relieve skin lesions,andimprove the immune function and sexual function of male patients with early syphilis,without increasing the risk of adverse reactions.