制备透明质酸衍生物交联剂的应用研究

RESEARCH OF CROSS-LINKING REAGENT FOR PRODUCING HYALURONIC ACID DERIVATIVE

目的 综述近年来国内外有关制备透明质酸衍生物交联剂的研究 ,为研制开发新型透明质酸提供选择。 方法 查阅国内外相关文献 ,对制备透明质酸衍生物交联剂的种类和特性、交联方法、交联机制进行综合分析。 结果 利用各种交联剂对透明质酸进行修饰 ,所得到的透明质酸衍生物保留了透明质酸良好的生物相容性 ,且流变学特性发生了改变 ,使其在组织内的存留时间延长。 结论 透明质酸衍生物的开发大大地拓展了透明质酸在医学领域的应用。

Objective To review the recent advances of cross-linking reagent for producing hyaluronic acid(HA) derivative so as to provide more advice for the development of HA reagent. Methods Recent original articles related to the species, characteristic, cross-linking methodology and mechanism of the cross-linking reagent to producing HA derivative were summarized and systematically analyzed. Results The derivatives after special kinds of reagents modification would remain their own good biocompatibility and change their original rheololgical characterization and obtain relative long organism residence time. Conclusion Development of hyaluronic derivatives may widen their medical application.