激素替代治疗对前列腺素和血栓素的影响

Effects of hormone replace therapy on 6-keto-postacycline and thromboxane B_2 in postmenopausal women

目的 探讨绝经后妇女激素替代治疗 (HRT)对 6 -酮 -前列腺素F1α(6 -K -PGF1α)和血栓素B2(TXB2 )的影响。方法 1 0 0例绝经后妇女随机分为A ,B两组 (各 50例 ) ,分别服 7-甲基异炔诺酮 2 5mg/d和维生素B6 1 0mg/d ,疗程 6个周期。另选 30例 2 5～ 45岁健康育龄妇女作为正常对照。监测服药前后患者的血浆 6 -K-PGF1α和TXB2 水平。结果 绝经后妇女 6 -K -PGF1α显著降低 ,而TXB2 显著升高。A组服药后 6 -K -PGF1α显著升高 ,TXB2 显著降低。B组服药前后 6 -K -PGF1α和TXB2 无明显改变。结论 HRT使绝经后妇女的 6 -K -PGF1α升高 ,TXB2 降低 ,这可能是HRT能预防冠心病的机制之一。

Objective To investigate the effects of hormone replace therapy(HRT) on 6-keto-postacycline(6-K-PGF 1α ) and thromboxane B 2(TXB 2) in postmenopausal women. Methods 100 cases were randomly assigned into group A and B(each with 50 cases). Patients in group A received livial 2.5 mg once daily, while vitamin B 6 10 mg once daily was given in group B. Plasma 6-K-PGF 1α and TXB 2 were measured before and after the therapy. Results The levels of 6-K-PGF 1α were significantly lower and TXB 2 were significantly higher in postmenopausal group. Plasma 6-K-PGF 1α values were significantly higher and TXB 2 values significantly lower than baselines in group A. There were no difference in 6-K-PGF 1α and TXB 2 concentrations in group B before and after therapy. Conclusion HRT results in an increased level of 6-K-PGF 1α and decreased level of TXB 2 in postmenopausal women. This may be one of the mechanisms by which HRT provides cardiovascular benefit.