猪流感病毒研究进展

Progress of Swine influenza virus

猪流感是由猪流感病毒引起的一种呼吸道传染病。目前 ,此病在世界各地都有发生 ,危害严重 ,经济损失巨大 ,并对人类的健康构成威胁。猪流感病毒属于正黏病毒科 A型流感病毒属 ,病毒粒子多形态。该病毒对热、消毒剂敏感 ,而对干燥和低温的抵抗力强大。其分子特性为多节段的 RNA病毒 ,由 8个片段组成 ,分别编码 1 0种蛋白质。猪流感病毒能够在多种动物的细胞上增殖 ,但病毒分离和疫苗生产时 ,经常采用鸡胚接种。病毒具有血凝活性 ,但不同毒株的抗原性无明显的区分。由于病毒受到抗体的压力很大 ,因此病毒的变异频繁 ,其机理涉及分子水平的抗原漂移和抗原转变。文章对病毒的理化、生物学特性、分子特性。

Swine influenza is a infectious respiratory disease by Swine influenza virus. Today, the disease which can result form economic lose and can threat animal husbandry and human health seriously takes place in many nation and region in the world. Swine influenza virus belong to influenza virus A, which was sensitive to physical and chemical factors, but was strong resistant to dry and cold. Swine influenza virus was composition of eight segments, which encode ten proteins. Swine influenza virus can multiply on many cells, but it was multiplied on embryo when it was applied for vaccine. Swine influenza virus can hemagglutinin red blood cell, but it have many difference among different sorts. Because of huge repression, swine influenza virus always vary, including antigen shift and antigen conversion. Because of swine influenza's serious economics and implication in public health, the authors analyze swine influenza virus's physical and chemical characterization, molecular characterization, biological characterization, swine influenza virus's proteins and so on.