急性冠脉综合征患者GRACE评分与N末端脑钠肽前体水平的相关性研究

Correlation between GRACE Score and Pro-brain Natriuretic Peptide in Patients with Acute Coronary Syndrome

目的探讨急性冠脉综合征(ACS)患者N末端脑钠肽前体(NT-pro BNP)与冠脉病变全球急性冠状动脉事件注册(GRACE)风险评分的相关性研究。方法选择137例ACS患者纳入ACS组,另选取经冠状动脉造影术后排除冠心病的老年患者89例作为对照组。入院24h内测定患者血浆NT-pro BNP,1周内行冠脉动脉造影术。采用GRACE评分标准对ACS组患者进行危险分层,分为低危组(53例)、中危组(44例)和高危组(40例)3个亚组。分析ACS患者血浆NT-pro BNP水平与GRACE评分的相关性及临床意义。结果与对照组相比,ACS患者NT-pro BNP水平明显升高,差异有统计学意义(P<0.01);ACS患者GRACE评分均高于正常组(P<0.01)。血浆NT-pro BNP水平与GRACE评分呈正相关关系(r=0.323,P<0.01))。结论NT-pro BNP水平与GRACE评分呈正相关,可用于对ACS患者的危险分层。

Objective To explore the relation between global registry of acute coronary events( GRACE) and pro-brain natriuretic peptide( NT-pro BNP) in patients with acute coronary syndromes( ACS). Methods137 ACS patients served as experimental group and 89 patients without coronary heart disease by coronary angiogram surgery served as a control group. Patients were taken blood sample for measurement of pro-brain natriuretic peptide within 24 hours after hospitalization coronary angiogram was applied to assess coronary heart disease within 1 week after hospitalization. ACS patients were further divided into low risk group( 53 cases),moderate risk group( 44 cases) and high risk group( 40 cases). Relation between NT-pro BNP and GRACE score was analyzed in experimental group. Results The NT-pro BNP level in ACS patients was significantly higher than that in control group( P < 0. 01). The GRACE score in ACS patients was significantly higher than that in control group( P < 0. 01). Conclusion Correlation analysis showed that NT-pro BNP levels were positive related with GRACE score in ACS patient and can predict the risk of ACS.