期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

尿中性粒细胞明胶酶相关脂质运载蛋白在造影剂肾病早期诊断的应用

下载PDF
导出
摘要 目的探讨尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)在冠状动脉诊疗术后造影剂肾病(CIN)早期诊断的临床价值。方法收集我院接受冠状动脉诊疗术患者186例,检测术前1天及术后2、6、24、48 h尿NGAL及血肌酐(Scr)水平。以血管内注射造影剂72h内,在排除其他发病因素的前提下,Scr绝对值升高﹥25%或Scr水平上升44μoml·L^(-1)作为CIN的诊断标准,其中14例发生CIN(CIN组)、172例未发生CIN(非CIN组)。结果两组患者术前血Scr、尿NGAL水平差异无统计学意义(P>0.05);非CIN组术后各时间点SCr、NGAL水平与术前差异无统计学意义(P>0.05);CIN组术后各时间点血Scr水平与术前差异无统计学意义(P>0.05);但尿NGAL水平较术前升高(P均<0.05);CIN组术后各时间点血Scr水平与非CIN组比较差异无统计学意义(P>0.05);但尿NGAL水平均高于非CIN组(P<0.05);CIN组术后48h血Scr水平(107.8±40.53)μmol·L^(-1)较术前(84.35±22.06)μmol·L^(-1)升高﹥25%,符合CIN诊断标准。结论尿NGAL在造影剂肾病(CIN)的早期诊断优于血Scr,可作为CIN早期诊断的标记物。
作者 夏春燕 任峥 陈淑红
机构地区 银川市第一人民医院
出处 《宁夏医科大学学报》 2015年第10期1220-1222,共3页 Journal of Ningxia Medical University
基金 宁夏医科大学科学研究基金项目(XM201345)
关键词 中性粒细胞明胶酶相关脂质运载蛋白 造影剂肾病 早期诊断
分类号 R541.4 [医药卫生—心血管疾病] R692 [医药卫生—泌尿科学]
  • 相关文献

参考文献12

  • 1吉俊,丁小强,许迅辉,邹建洲,何建强,林贻梅,柏瑾,钱菊英.低渗非离子造影剂对冠状动脉介入诊疗术患者肾功能影响的前瞻性研究[J].中华肾脏病杂志,2006,22(7):388-392. 被引量：46
  • 2E. Singer,L. Markó,N. Paragas,J. Barasch,D. Dragun,D. N. Müller,K. Budde,K. M. Schmidt‐Ott.??Neutrophil gelatinase‐associated lipocalin: pathophysiology and clinical applications(J)Acta Physiol . 2013 (4)
  • 3Aldo Clerico,Claudio Galli,Antonio Fortunato,Claudio Ronco.??Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker of acute kidney injury: a review of the laboratory characteristics and clinical evidences(J)Clinical Chemistry and Laboratory Medicine . 2012 (9)
  • 4Dong-Ho Shin,Dong-Ju Choi,Tae-Jin Youn,Chang-Hwan Yoon,Jung-Won Suh,Kwang-Il Kim,Young-Seok Cho,Goo-Yeong Cho,In-Ho Chae,Cheol-Ho Kim.??Comparison of Contrast-Induced Nephrotoxicity of Iodixanol and Iopromide in Patients With Renal Insufficiency Undergoing Coronary Angiography(J)The American Journal of Cardiology . 2011 (2)
  • 5Davide Bolignano,Valentina Donato,Giuseppe Coppolino,Susanna Campo,Antoine Buemi,Antonio Lacquaniti,Michele Buemi.??Neutrophil Gelatinase–Associated Lipocalin (NGAL) as a Marker of Kidney Damage(J)American Journal of Kidney Diseases . 2008 (3)
  • 6Kimmel Martin,Butscheid Moritz,Brenner Stefanie,Kuhlmann Ulrich,Klotz Ulrich,Alscher Dominik Mark.Improved estimation of glomerular filtration rate by serum cystatin C in preventing contrast induced nephropathy by N-acetylcysteine or zinc--preliminary results. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association . 2008
  • 7Michael Zappitelli,Kimberly K Washburn,Ayse A Arikan,Laura Loftis,Qing Ma,Prasad Devarajan,Chirag R Parikh,Stuart L Goldstein.Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. Journal of Critical Care . 2007
  • 8Jin Wi,Young-Guk Ko,Jung-Sun Kim.Impact of contrast-induced acute kidney injury with transient or persistent renal dysfunction on long-term outcomes of patients with acute myocardial infarction undergoing percutaneous coronary intervention. Heart . 2011
  • 9Feldkamp T,Kribben A.Contrast media induced nephropathy: definition, incidence, outcome, pathophysiology, risk factors and prevention. Minerva Medica . 2008
  • 10Ling Wang,Zhaohui Ni,Ben He,Leyi Gu,Jianping Liu,Huili Dai,Jiaqi Qian.Urinary IL-18 and NGAL as early predictive biomarkers in contrast-induced nephropathy after coronary angiography. Nephron. Clinical practice . 2008

二级参考文献26

  • 1Best PJ,Lennon R,Ting HH,et al.The impact of renal insufficiency on clinical outcomes in patients undergoing percutaneous coronary interventions.J Am Coll Cardiol,2002,39:1113-1119.
  • 2McCullough PA,Wolyn R,Rocher LL,et al.Acute renal failure after coronary intervention:incidence,risk factors,and relationship to mortality.Am J Med,1997,103:368-375.
  • 3Davidson C J,Laskey WK,Hermiller JB,et al.Randomized trial of contrast media utilization in high-risk PTCA:the COURT trial.Circulation,2000,101:2172-2177.
  • 4Cigarroa RG,Lange RA,Williams RH,et al.Dosing of contrast material to prevent contrast nephropathy in patients with renal disease.Am J Med,1989,86:649-652.
  • 5Solomon R.The role of osmolality in the incidence of contrast-induced nephropathy:a systematic review of angiographic contrast media in high risk patients.Kidney Int,2005,68:2256-2263.
  • 6Rihal CS,Textor SC,Grill DE,et al.Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention.Circulation,2002,105:2259-2264.
  • 7Rich MW,Crecelius CA.Incidence,risk factors,and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older.A prospective study.Arch Intern Med,1990,150:1237-1242.
  • 8Manske CL,Sprafka JM,Strony JT,et al.Contrast nephropathy in azotemic diabetic patients undergoing coronary angiography.Am J Med,1990,89:615-620.
  • 9Curhan GC.Prevention of contrast nephropathy.JAMA,2003,289:606-608.
  • 10Morcos SK,Thomsen HS,Webb JA.Contrast-media-induced nephrotoxicity:a consensus report.Contrast Media Safety Committee,European Society of Urogenital Radiology (ESUR).Eur Radiol,1999,9:1602-1613.

共引文献53

宁夏医科大学学报
2015年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部