VEGF基因多态性与复发性自然流产关联性的Meta分析

Vascular Endothelial Growth Factor Gene Polymorphisms and Recurrent Spontaneous Abortion: a Meta- Analysis

目的了解VEGF基因多态性与复发性自然流产(RSA)的关系。方法检索收集国内外数据库2014年11月之前公开发表的关于VEGF基因多态性与RSA相关性的病例-对照研究,剔除不符合要求的文献,采用Rev Man 5.1软件进行数据分析。结果纳入符合标准的已发表文献12篇。Meta分析显示:rs1570360位点各研究在共显性模型下异质性差异显著(I2=67%,P=0.004),采用随机效应模型,合并OR及95%可信区间为1.26(1.00~1.58),P=0.05;rs699947位点各研究在共显性模型下异质性无意义(I2=31%,P=0.18),采用固定效应模型,合并OR及95%可信区间分别为0.95(0.85~1.06),P=0.33;rs3025039位点各研究在共显性、显性及隐性模型下异质性差异均无统计学意义(I2<50%,P>0.05),采用随机效应模型,各模型合并OR及95%可信区间分别为1.48(1.17~1.88)、1.61(1.35~1.93)、2.75(1.65~4.57)(P均<0.05)。结论 VEGF基因rs1570360、rs699947多态性与RSA无明显相关性,VEGF基因rs3025039多态性与RSA存在一定的相关性。

Objective To explore the relationship between VEGF gene polymorphism and recurrent spontaneous abortion( RSA). Methods Published case- control studys about relationship between VEGF gene polymorphism and RSA were searched and collected in periodical database at home and abroad. Review Manager5. 1 program was used for Meta- analysis. Results 12 studies up to standard were collected. Research on rs1570360 under the codominant model showed a significant heterogeneity( I2= 67%,P = 0. 004) and the random effects model was taken while the combined OR and 95% confidence region was 1. 26( 1. 00 ~ 1. 58),P = 0. 05. Researches on rs699947 under dominant model showed no significant heterogeneity( I2= 31%,P =0. 18) and the fixed effects model was chose while the combined OR and 95% confidence region was 0. 95( 0. 85 ~ 1. 06),P = 0. 33. Researches on rs3025039 under each model showed no significant heterogeneity( I2< 50%,P > 0. 05) and the random effect model was chose while the combined OR and 95% confidence region in codominant,dominant and recessive model were 1. 48( 1. 17 ~ 1. 88),1. 61( 1. 35 ~ 1. 93) and 2. 75( 1. 65 ~ 4. 57)( P < 0. 05). Conclusions rs3025039( C /T) may be associated with RSA. No significant correlation was found between the polymorphisms( rs1570360( G / A),rs699947( C / A)) and RSA.