电刺激红核对WDR神经元C反应的抑制作用

INHIBITORY EFFECT OF RED NUCLEUS STIMULATION ON C-RESPONSE OF WDR NEURONS

目的 :分析红核的抗伤害作用和有关机制。方法 :用玻璃微电极细胞外记录大鼠脊髓背角广动力型神经元 (widedynamicrange ,WDR)的单位放电 ,观察电刺激红核对WDR神经元伤害性反应 (C 反应 )的影响。结果 :电刺激红核对WDR神经元C 反应具有抑制作用。电刺激红核对同侧WDR神经元C 反应的抑制作用弱于对侧。静注纳洛酮对电刺激红核的抑制作用无明显的影响。结论 :红核参与伤害信息的处理 ,阿片机制似不参与上述作用。

Objective:To analyze the antinociceptive effect of red nucleus (RN) and the involved mechanism. Methods:The single units of wide dynamic range (WDR) neurons in the spinal cord dorsal horn were recorded extracelluarly. The effects of RN stimulation on nociceptive responses (C-fibres-evoked responses, C-responses) of WDR neurons were observed. Results: 1. Stimulation in RN caused a significant reduction of nociceptive response of WDR neurons. 2.The effect of RN stimulation on contralateral WDR neurons was more powerful than that on ipsilateral WDR neuron. 3. The inhibitory effect produced by RN stimulation was not reversed by intravenous naloxone. Conclusion:The results suggested that RN might be involved in the antinociception in a naloxone-nonreversible manner.