绝经期妇女骨密度改变与血浆白细胞介素-6关系的探讨

Relationship Between Changes of Bone Mineral Density and Serum Interleukin-6Level in Postmenopausal Women

目的观察绝经后妇女骨密度 (BMD)改变与血浆白细胞介素 -6(IL -6)的关系。方法应用单光子骨密度仪测量非优势前臂尺桡骨中远端1/3交界处桡骨BMD ,小于0.601g/cm2则诊断为骨质疏松 ,据此将38名绝经期妇女分为绝经后非骨质疏松组和绝经后骨质疏松组两组 ,测定其外周血IL-6浓度及其他代谢指标。结果两组年龄、身高、体质量、体质量指数、血钙、血磷、血清总雌二醇、总睾酮均无显著性差异 (P>0.05)。绝经年限、血总碱性磷酸酶 (ALP)、血清骨钙素 (BGP)、骨密度、血浆IL -6浓度有显著性差异(P<0.05)。结论绝经后雌激素水平下降 ,血浆IL -6分泌增加 ,促进骨吸收增加 ,随时间的延长导致骨质疏松形成。

Objective To investigate the relationship between changes of bone mineral density and serum inˉterlerkin-6level in postmenopausal women.Methods BMD at the junction of the middle and the distal thirds of non-dominant ulna was measured by single photon bone denstometer in38postmenopausal women.BMD<0.601g/cm 2 serves as the diagnostic criterion for osteoporosis.According to this,38women were divided into two groups:normal postmenopausal group(n=20,mean age57±4)and postmenopausal osteoporotic group(n=18,mean age59±5).The release of IL-6and other marker of bone metabolism were determined.Results There were no sigˉnificant differences between two groups in age,stature,weight,BMI,serum calcium and phosphorus,E 2 ,and T(P>0.05).There were significant differences between two groups in menopause duration,ALP,BGP,BMD,and IL-6(P>0.05).Conclusions The decrease in E 2 level after menopause is the main factor in promoting the secretion of IL-6,the high level of IL-6activates osteoclasts,with the elapse of time resulting in osteoporosis.