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腺苷受体激动剂延迟预处理与核转录因子-κB的关系 被引量：3

Relation Between Nuclear Factor-κB and Delayed Preconditioning Induced with Adenosine Receptor Analogue
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摘要 目的了解以腺苷A1 受体激动剂 (PIA)延迟预处理与核转录因子(NF -κB)的关系。方法大白兔随机分3组。A组 :以PIA预处理 ;K组 :除抑制NF-κB外同A组 ;C组 :对照。24h后建立离体心脏模型,观察心功能和ATP等。结果缺血 -复灌后A组心功能恢复率、ATP含量高于C、K组 ,差异均有显著性 (P<0.05或P<0.01),而K组与C组差异无显著性。结论在以PIA延迟预处理中 ,NF-κB可能起着信号传导作用。 Objective To study the relation between NF-κB and delayed preconditionig with adenosine A 1 receptor agonist.Methods The male rabbits in group A,K,C were preconditioned with adenosine A 1 receptor agˉonist PIA,PDTC+PIA,vehicle of PIA,respectively.the rabbit hearts were isolated and perfused with H-K buffer solution on the Langendorff apparatus after24hours,and then subjected to150minutes hypothermic isˉchemia and reperfused for60minutes.Results Cardiac output recovery rate and myocardial ATP content in group A were significantly higher than those of group K and C(P<0.05or P<0.01),while the difference between group C and K was not significant.Conclusions NF-κB may mediate the delayed preconditioning with A 1 reˉceptor analogue in rabbit heart.
作者 朱水波 刘孟丽 孙宗全 殷桂林 庞大志 唐英 王晓昆
机构地区 广州军区武汉总医院心胸外科 华中科技大学协和医院心外科 广州军区武汉总医院实验中心
出处 《中国微循环》 2003年第6期341-342,共2页 Journal of Chinese Microcirculation
关键词 转录因子 心脏预处理 腺苷 Nuclear factor Preconditioning Adenosine
分类号 R654.2 [医药卫生—外科学]
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参考文献5

  • 1[1]Baxter GF, Yellon DM. Time coure of delayed myocardial protection after transient adenosine A 1 -receptor activation in the rabbit [J]. J Cardiovasc Pha- rmacol. 1997,29:631～ 638
  • 2[2]Thornton JD, Liu GS, Olsson RA, et al. Intrevenous pretreatment with A 1 -selective adenosine analogues protects the heart against infarction[J]. Circulation. 1992,85:659～ 665
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  • 4[4]Xuan YT, Tang XL, Banerjee S, et al. Nuclear factor - kB plays an essential role in the late phase of ischemic preconditioning in conscious rabbits[J]. Circ Res. 1999,84:1095～ 1109
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同被引文献17

  • 1Takano H,TangX L,Bolli R.Differential role of KATP channels in late preconditioning against myocardial stunning and infarction in rabbits[J].Am J Physiol.2000,279:2350～2359
  • 2Zhao TC,Hines DS,Kukreja RC.Adenosine induced late preconditioning in the mouse hearts:role p38 MAP kinase and mitochondrial KATP channels[J].Am J Physiol.2001,280(3):1278～1285
  • 3Baxter GF,Yellon DM.Time course of delayed myocardial protection after transient adenosine A1-receptor activation in the rabbit[J].J Cardiovasc Pharmacol.1997,29:631～638
  • 4Fryer RM,Wang YG,Hsu AK,et al.Essential activation of PKC-δ in opioid-initiated cardioprotection[J].Am J Physiol Heart Circ Physiol.2001,280(3):1346-1353.
  • 5McPherson BC,Yao Z.Morphine mimics preconditioning via free radical signals and mitochondrial KATP channels in myocytes[J].Circulation.2001,103(2):290-295.
  • 6Gross ER,Hsu AK,Gross GJ.Opioid-Induced cardioprotection occurs via glycogen synthase kinase {beta} inhibition during reperfusion in intact rat hearts[J].Circ Res.2004,94(7):960-966.
  • 7Kodani E,Xuan YT,Shinmura K,et al.Delta -Opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits[J].Am J Physiol Heart Circ Physiol.2002,283(5):1943-1957.
  • 8Weil J,Eschenhagen T,Fleige G,et al.Localization of preproenkephalin Mrna in rat heart:selective gene expression in left ventricular myocardium[J].Am J Physiol Heart Circ Physiol.1998,275:378-384.
  • 9Shinmura K,Nagai M,Tamaki K,et al.COX-2-derived prostacyclin mediates opioid-induced late phase of preconditioning in isolated rat hearts[J].Am J Physiol Heart Circ Physiol.2002,283(6):2534-2543.
  • 10Cao ZP,Liu LJ,Van Winkle DM.Activation of δ-and -κ opioid receptors by opioid peptides protects cardiomyocytes via KATP channels[J].Am J Physiol Heart Circ Physiol 2003,285(3):1032-1039.

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中国微循环
2003年 第6期

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