奎的平、氯丙嗪对精神分裂症患者血清催乳素的影响

Effects of quetiapine and chlorpromazine on serum prolactin of schizophrenics

目的 研究服用奎的平和氯丙嗪对精神分裂症患者PPL的影响。方法 对15例服用奎的平(研究组),15例服用氯丙嗪(对照组)的符合入组标准的30例精神分裂症患者治疗前和治疗6w后的血清PRL浓度分别进行测定,并对统计结果进行方差分析。结果 奎的平组治疗后与治疗前血清PRL浓度(7.21±3.88μg·L-1/6.42±4.14μg·L-1)比较无显著差异(P>0.05);氯丙嗪组治疗前后血清:PRL,浓度(6.53±4.26μg·L-1/31.83±12.98μg·L-1)比较有显著差异(P<0.001);奎的平组与氯丙嗪组治疗后血清PRL浓度有极显著性差异(P<0.001)。结论非典型抗精神病药奎的平对精神分裂症患者血清PRL影响小于传统抗精神病药物氯丙嗪。

Objective To explore the effects of qurtiapine and chlorpromazine on serum prolactin of schizophrenics. Methods Thirty schizophrenics were randomly assigned to quetiapine group (n = 15) and chlorpromazine group (n =15) . Serum prolactin was tested before and after six weeks treatment, respectively. Results There was no significant difference of serum prolactin before and after treatment in quetiapine group ( P > 0.05) ; while the serum prolactin after treatment was significantly higher than that before treatment in chlorpromazine group( P < 0.001) ; after treatment, there was more significant difference in serum prolactin between the two groups (P < 0.001) . Conclusion The effect of quetiapine on serum prolactin was smaller than that of chlorpromazine.