长期住院精神分裂症患者迟发性运动障碍调查

The investigative analysis of tardive dyskinesia in chronic schizopnrenia

目的 :探讨住院 8年以上的男性精神分裂症患者的迟发性运动障碍 (TD)的发生率及其危险因素。 方法 :对住院 8年以上的男性精神分裂症患者 193例使用异常不自主运动量表 (AIMS)评定患者有无TD及其严重程度。 结果 :TD总的发生率为 2 4 .9%。TD组的当前服药剂量高 ,服用高效价药多 ,联用苯海索多。 结论 :服药剂量的高低及高效价药和苯海索的使用可能会影响到TD的发生。

Objective:To assessing the prevalence and risk factors of tardive dyskinesia(TD) in male chronic schizophrenic patients who had been in hospital for over 8 years. Method:193 inpatients with scizophrenia were involved in this research.The diagnosis of TD was made according to the abnormal involuntary movement scale(AIMS) score. Results:24.9%(48/193) of patients had TD.The prevalence of TD were higher in patients who took high value or higher of neuroleptics or trihexyphenidyl. Conclusion:It is indicated that using of high value and high dose neuroleptics and trihexyphenidyl be high risk factors for developing of TD.