同型半胱氨酸与急性缺血性脑血管患者预后的相关性

Study on Correlation Between Homocysteine and Prognosis of Patients with Acute Ischemic Cerebrovascular Disease

目的探讨同型半胱氨酸(Hcy)与急性缺血性脑血管(AICD)患者预后的相关性。方法选取2009年6月至2015年9月我院神经内科收治的92例AICD患者(研究组)及同期来我院体检的82例健康志愿者(对照组)为研究对象,对两组研究对象Hcy水平、凝血指标[血小板计数(PLT)、活化部分凝血活酶时间(a PTT)、纤维蛋白原(Fbg)、血浆凝血酶时间(TT)]进行测定,并分析HCY水平与患者美国国立卫生研究院卒中量表(NIHSS分级)相关性及与疾病预后关系。结果研究组Hcy表达水平(19.35±7.25)μmol/L较对照组(8.98±2.68)μmol/L显著高,有统计学意义(P<0.05);研究组a PTT、TT、PLT表达水平较对照组低(P<0.05)。Fbg(5.21±0.69)g/L表达水平较对照组高(P<0.05);不同表达水平的Hcy、NIHSS分级类型差异显著(P<0.05);Hcy表达水平高低与疾病预后相关性显著。结论Hcy可作为AICD独立预测因子。

Objective To explore correlation between homocysteine( Hcy) and prognosis of patients with acute ischemic cerebrovascular disease( AICD). Methods 92 patients with treated in department of neurology of our hospital from June 2009 to September 2015( study group) and 82 healthy examinees in the same period( control group) were selected as the research objects,HCY level,coagulation indexes[platelet count( PLT),activated partial thromboplastin time( a PTT),fibrinogen( Fbg),plasma thrombin time( TT) ]in the two groups were measured,correlation between Hcy level and the national institutes of health stroke scale( NIHSS grade) and its relationship with prognosis were analyzed. Results Hcy expression level of study group( 19. 35 ± 7. 25) μmol / L was significantly higher than the control group[( 8. 98 ± 2. 68) μmol / L]( P <0. 05); a PTT,TT,PLT of study group were significantly lower than the control group( P < 0. 05); Fbg expression level was significantly higher than the control group( P < 0. 05); in Hcy of different expression levels,NIHSS grading types were significant( P < 0. 05); correlation between Hcy expression level high and low and prognosis were significant( P < 0. 05). Conclusion Hcy can be used as an independent predictor of AICD.