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介入治疗与药物治疗在对脑梗死患者凝血-纤溶功能的影响及疗效比较 被引量:6

Interventional Therapy and drug Treatment in Blood Coagulation and Fibrinolytic Function in Patients with Cerebral Infarction and the Influence of the Curative Effect Comparison
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摘要 目的研究介入及药物治疗对脑梗死患者凝血-纤溶功能的影响与疗效比较。方法选择2013年4月至2015年4月我院80例脑梗死患者作为研究对象,根据病情和患者意愿,其中观察组48例行介入手术治疗,对照组32例行单纯药物治疗。观察两组治疗效果及对患者凝血纤溶功能的影响。结果观察组治疗后总有效率为83.33%,对照组为59.38%,组间比较,差异有统计学意义(P<0.05)。观察组死亡率为14.58%,对照组为34.38%,组间比较,差异有统计学意义(P<0.05)。观察组治疗后组织型纤溶酶原激活物(t-PA)和血浆血管性血友病因子(v WF)分别为(19.87±3.07)ug/L和(2.67±0.81)IU/m L,显著高于治疗前和对照组治疗后,血浆纤溶酶原激活物抑制剂-1(PAI-1)为(51.19±5.62)ug/L,显著低于治疗前和对照组治疗后,差异均有统计学意义(P<0.05)。两组并发症比较,差异无统计学意义(P>0.05)。结论介入治疗脑梗死效果显著,能显著降低死亡率,改善凝血纤溶功能,在具体操作时应严格操作流程,尽量减少对血管内皮细胞的损伤,减少出血并发症。
出处 《血栓与止血学》 2017年第1期115-117,共3页 Chinese Journal of Thrombosis and Hemostasis
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