类风湿性关节炎患者血浆D二聚体纤维蛋白原及25羟基维生素D检测的临床价值

Clinical Value of Plasma of D-dimer、Fibrinogen、and 25-( OH) Vitamin D Detection in Patients with Rheumatoid Arthritis

目的为探讨类风湿性关节炎(RA)患者血浆D二聚体(D-D)、纤维蛋白原(Fbg)、25羟基维生素D(25OHD)联合检测的临床价值。方法采用SysmexCS2000i全自动血凝仪对110例类风湿性关节炎(RA)患者及150例健康体检者血浆D-D、Fbg、25OHD分别进行检测,并进行比较。结果类风湿性关节炎(RA)患者血浆D--D、Fbg水平明显高于健康对照组(P<0.01);25OHD水平显著低于健康对照组(P<0.01)。结论 RA患者血浆D-D及Fbg水平升高、25OHD水平降低,且与疾病活动性相关,可以作为判断RA患者疾病活动性的参考指标。

Objective To investigate the rheumatoid arthritis(RA)patients with plasma D-dimer(D-D),fibrinogen(Fbg),and 25-hydroxy vitamin D(25 OHD)combined detection of clinical value.Methods SysmexCS2000 i automatic blood coagulation analyzer 110 cases with RA patients and 150 cases of healthy persons plasma D-D,Fbg and 25-OHD were respectively detected and compared.,Results RA patients with plasma D-D and Fbg levels were significantly higher than healthy controls(P<0.01);The levels of 25 OHD were significantly lower than healthy controls(P<0.01).Conclusion RA patients with high D-D and Fbg levels,low 25 OHD levels and were associated with disease activity.They can regard as the index which determine the disease activity in RA patients.