动态监测孕妇抗体效价的意义

Clinical significance of dynamic monitoring antibody titer in pregnant women

目的 :探讨动态监测O型孕妇血清中IgG抗A(B)血型抗体的效价 ,与新生儿溶血病 (HDN)的关系。方法 :对392例O型孕妇在孕20、26、30、34、38周动态监测血清中IgG抗A(B)的效价 ,检查新生儿血型 ,并作3项实验 (Coombs试验、抗体释放及游离抗体测定 )以确诊HDN。结果 :当IgG抗A(B)抗体效价升高2个及以上滴度时 ,其HDN的发病率为83 %。结论 :动态监测孕妇血清中IgG抗A(B)

Objective:To study the relationship between the antibody titer of serum anti-A(B)blood type of IgG and hemolytic disease of mewborn(HDN)in pregnant women with0blood type by dynamic monitoring.Methods:The titer of serum anti-A(B)blood type of IgG in392 pregnant women with0blood type in pregnant20,26,30,34,38weeks was dynamicly monitored respectively.The blood type of newborn was deˉtected,and three items of test,namely coombs test,antibody release and free antibody determination were done for the diagnosis of HDN.Results:When the antibody titer of serum anti-A(B)blood type of IgG rose to two titers or more,the morbidity of HDN was83%.Conclusion:Dynomic monitoring the antibody titer of serum anti-A(B)blood type of IgG has important significance on the prevention of HDN.