广州管圆线虫感染致病机制的研究进展

Advances in pathogenic mechanisms of Angiostrongylus cantonensis infection

广州管圆线虫病是因感染了广州管圆线虫后其幼虫移行至宿主中枢神经系统,从而引起以嗜酸性粒细胞增多为特征、以脑炎和脑膜脑炎为主要临床表现的一种危害严重的食源性寄生虫病,阐明其致病机制对于广州管圆线虫病防治具有重要意义。本文主要就广州管圆线虫感染引起嗜酸性粒细胞增多性脑炎和脑膜脑炎机制研究进展作一综述。

Angiostrongylosis,a food-borne parasitic disease,is caused by the migration of larvae of Angiostrongylus cantonensis to the host’s central nervous system after it is infected.It is a serious disease with eosinophilic encephalitis and meningoencephalitis as the main clinical manifestations.Understanding of its pathogenic mechanism is important for the prevention and treatment of angiostrongylosis.This paper reviews the mechanism of eosinophilic meningitis and meningoencephalitis caused by A.cantonensis infection.