促进血管钙化的主要机制及其研究进展

The Main Mechanism of Promoting Vascular Calcification and Its Research Progress

随着社会老龄化的加重,血管钙化的发生日益普遍。众多疾病诸如糖尿病、血脂代谢异常症、肾病都是血管钙化的明确诱因,血管钙化也反过来促进心脑血管事件的发生。尽管血管钙化进程的研究发现众多,仍有很多问题是未知的。现重点讨论遗传、细胞表型转化、炎症因子、磷酸盐等对血管钙化的影响,旨在引起临床工作人员及科研人员对血管钙化方面的重视,并致力于血管钙化的研究工作。

With the aging of society,the occurrence of vascular calcification is increasingly common. Numerous diseases such as diabetes,dyslipidemia, and nephropathy are definite causes of vascular calcification. Vascular calcification also in turn promotes cardiovascular and cerebrovascular events. Despite numerous findings of vascular calcification,many problems remain unknown. This review focuses on genetic,cellular phenotypic changes,inflammatory factors,phosphates and other effects on vascular calcification,aims to cause attention to vascular calcification,and devote to the study of vascular calcification.