蛇婆子地上部分化学成分研究（英文）

Chemical constituents from the aerial parts of Waltheria indica Linn.

运用多种色谱和波谱方法对蛇婆子地上部分的化学成分进行研究,从中分离鉴定了16个化合物,包括5个萜类(1–5),4个香豆素(6–9),6个黄酮(10–15)和1个其它类化合物(16)。除了化合物12和15外,其余14个化合物均为首次从蛇婆子中分离得到,其中香豆素类化合物为首次报道从蛇婆子中分离得到。对分离得到的16个化合物进行了体外NO生成抑制活性筛选,结果显示化合物10, 13和14有弱的NO生成抑制活性。

A phytochemical investigation on the aerial parts of Waltheria indica Linn.led to the isolation of 16 compounds,including five terpenoids(1–5),four coumarins(6–9),six flavonoids(10–15),and one phenylpropanoid glycoside(16).The structures of these compounds were identified by spectroscopic data analysis and comparison with those reported in the literatures.Except for 12 and 15,all the compounds were isolated from W.indica for the first time.Moreover,coumarins were firstly reported to be obtained from this herb.The NO production inhibitory activities of all the isolated compounds in LPS-induced BV-2 cells were also presented.