Synthetic studies toward resveratrol-based natural products polynapstilbenes A and B

白藜芦醇衍生天然产物Polynapstilbenes A和B的合成研究（英文）

Resveratrol-based natural products have received considerable attention as synthetic targets due to their versatile bioactivities and unique structures.Herein,we disclose our efforts toward the syntheses of polynapstilbenes A and B,which possess[C8-O-C-C-C7]-type dihydrobenzofuran skeleton that is distinctive compared with the other reported resveratrol-derived natural products.Our approach,featuring an acid-catalyzed conjugate addition followed by cyclization of para-quinone methides and phenols,affords two advanced intermediates that represents the dimethyl-protected aglycon of polynapstilbenes A and B.

本文报导了一种区域选择性合成基于白藜芦醇的[C8-O-C-C-C7]二氢苯并呋喃天然产物骨架的方法,并据此合成了天然产物Polynapstilbenes A和B的合成中间体。