地西泮联合苯巴比妥治疗小儿高热惊厥疗效临床分析

Clinical analysis of diazepam combined with phenobarbital in the treatment of children with febrile seizures

目的分析地西泮联合苯巴比妥治疗小儿高热惊厥疗效。方法将2016年4月-2017年1月84例小儿高热惊厥患儿随机分两组。单一治疗组仅给予苯巴比妥治疗,联合治疗组则给予地西泮联合苯巴比妥治疗。比较两组高热惊厥治疗总有效率;体温正常时间、惊厥状态持续时间、住院时间;癫痫、共济失调、脑障碍综合征等并发症出现率。结果联合治疗组高热惊厥治疗总有效率高于单一治疗组,P<0.05;联合治疗组体温正常时间、惊厥状态持续时间、住院时间短于单一治疗组,P<0.05;联合治疗组癫痫、共济失调、脑障碍综合征等并发症出现率显著低于单一治疗组,P<0.05。结论地西泮联合苯巴比妥治疗小儿高热惊厥疗效临床确切,可在短时间内控制临床症状,减少并发症的发生,改善患儿预后,值得推广。

Objective To analyze the efficacy of diazepam combined with phenobarbital in the treatment of children with febrile seizures. Methods Eighteen children from April 2016 to January 2017 were randomly divided into two groups. In the single treatment group,phenobarbital was given only,and the combination therapy group was treated with diazepam combined with phenobarbital. The incidence of complications such as epilepsy,ataxia,and brain disorder syndrome were significantly higher than those in the control group( P<0. 05). Results The total effective rate was higher in the combination therapy group than that in the single treatment group( P<0. 05). The duration of the patients was shorter than that of the single treatment group( P<0. 05). The combined treatment group had epilepsy,The incidence of complications such as ataxia and brain disorder syndrome was significantly lower than that of single treatment group( P<0. 05). Conclusion Dipiazepine combined with phenobarbital in the treatment of children with febrile seizures is clinically accurate and can control clinical symptoms in a short time,reduce the incidence of complications and improve the prognosis of children.