特发性肺间质纤维化与继发于结缔组织病的肺间质病比较

Comparison of idiopathic pulmonary fibrosis and pulmonary interstitial disease secondary to connective tissue disease

目的对比特发性肺间质纤维化(IPF)与继发于结缔组织病(SPF)表现差异。方法设一组50例IPF患者(A组)与50例SPF患者(B组)对比试验。结果 A组气短、杵状指、咳嗽、Vecrlo音症状明显高于B组(P<0.05);两组实验室检查中混合感染、真菌感染差异无统计学意义(P>0.05);CT表现中,A组主要表现为网状阴影,B组更多见于胸膜受累,P<0.05。结论临床诊断IPF与SPF中,应重视影像学与肺功能检查,若患者出现网络状改变应考虑IPF的可能性,若表现胸膜受累则应考虑SPF的可能性。

Objective To compare the difference between idiopathic pulmonary fibrosis( IPF) and secondary connective tissue disease( SPF). Methods a group of 50 patients with IPF( group A) and 50 patients with SPF( group B) contrast test. Results in A group,shortness of breath,clubbing,cough,Vecrlo rales symptoms was significantly higher than B group( P<0. 05); two groups of laboratory mixed infection,fungal infection had no significant difference( P > 0. 05); CT,A groups were reticular opacities,B group is more common in the chest film the involvement of P is less than 0. 05. Conclusion in clinical diagnosis of IPF and SPF,attention should be paid to the imaging and pulmonary function tests. If the patient changes in the network,the possibility of IPF should be considered. If the pleural involvement is involved,the possibility of SPF should be considered.