小胶质细胞的分泌作用对神经损伤后修复的影响

The effect of microglial secretion on repair after nerve injury

在过去的很长一段时间内,大脑被认为是不可再生器官的传统观念已经发生了改变,其在损伤后仍具有一定的再生能力。小胶质细胞作为在中枢神经系统中固有的具有免疫功能的细胞,其在中枢神经系统损伤修复中的作用已经引起了广泛的关注。目前,越来越多的研究证明其细胞表型的改变及活化状态,可以影响其分泌各种神经毒性和神经营养的因子,从而起到双相调控的作用。为了更细化的了解其分泌作用,本综述就MG在静息及活化2种状态的分泌物,以及分泌物在神经元再生中的可能发挥的作用进行总结。

For a long time,the traditional view of the brain as a non-regenerative organ has changed,and it is still capable of regeneration after injury. As an innate immune function in the central nervous system,microglial cells have attracted extensive attention in the repair of central nervous system damage. At present,more and more studies have proved that the change and activation of cell phenotype can affect the secretion of various neurotoxic and neurotrophic factors,thus playing a role of dual phase regulation. In order to understand the secretion effect more,this review summarizes the role of MG in resting and activating 2 states and the potential role of secretions in regeneration of neurons.