氨溴索联合CPAP治疗新生儿呼吸窘迫综合征疗效

Therapeutic effect of ambroxol combined with CPAP on neonatal respiratory distress syndrome

目的探讨氨溴索联合CPAP治疗新生儿呼吸窘迫综合征的效果。方法随机选取2013年8月—2016年8月江苏省徐州市丰县人民医院新生儿呼吸窘迫综合征患儿100例,按先后序列号(1～100)随机分为氨溴索联合CPAP治疗组(联合治疗组,50例)和单独CPAP治疗组(单独治疗组,50例)。给予两组患儿一般治疗,为患儿保温,严密监测患儿生命体征,将患儿酸中毒纠正过来,给予患儿营养支持、抗感染等治疗。然后给予单独治疗组患儿CPAP治疗,联合治疗组患儿接受氨溴索联合CPAP治疗,同时给予患儿静脉输注盐酸氨溴索治疗,连用3d。观察并比较两组患儿的临床疗效及发绀、气促、三凹征等症状体征消失时间及住院时间。结果联合治疗组患儿中显效32例,有效14例,治疗的总有效率为92.0%(46/50);单独治疗组患儿中显效11例,有效26例,治疗的总有效率为74.0%(37/50)。联合治疗组患儿治疗的总有效率显著高于单独治疗组(P <0.05)。联合治疗组患儿中显效32例,有效14例,治疗的总有效率为92.0%(46/50);单独治疗组患儿中显效11例,有效26例,治疗的总有效率为74.0%(37/50)。联合治疗组患儿治疗的总有效率显著高于单独治疗组(P <0.05)。联合治疗组患儿的发绀消失时间、气促消失时间、三凹征消失时间、住院时间均显著短于单独治疗组(P <0.05)。结论氨溴索联合CPAP治疗新生儿呼吸窘迫综合征的效果优于单独CPAP的治疗效果。

Objective To investigate the effect of ambroxol combined with CPAP in the treatment of neonatal respiratory distress syndrome and provide reference for clinical treatment.Methods A total of 100 children with neonatal respiratory distress syndrome in Fengxian People’s Hospital of Xuzhou City,Jiangsu Province from August 2013 to August 2016 were randomly selected.The serial number(1~100) was randomly divided into ambroxol combined with CPAP treatment group.The combination treatment group(50 cases) and the CPAP treatment group alone(50 cases in the treatment group alone).The two groups of children were given general treatment,the children were kept warm,the vital signs of the children were closely monitored,the acidosis of the children was corrected,and the children were given nutritional support and anti-infection treatment.Then,CPAP was given to the children in the treatment group alone.The patients in the combination group received ambroxol combined with CPAP,and the children were given intravenous infusion of ambroxol hydrochloride for 3 days.The clinical efficacy of the two groups of children and the disappearance time and hospitalization time of symptoms and signs such as cyanosis,shortness of breath and three concave signs were observed and compared.Results In the combined treatment group,32 cases were effective and 14 cases were effective.The total effective rate was 92.0%(46/50).In the treatment group,11 cases were effective and 26 cases were effective.The total effective rate was 74.0.%(37/50).The total effective rate of treatment in the combined treatment group was significantly higher than that in the treatment group alone(P<0.05).The disappearance time,the time of disappearance of shortness of breath,the disappearance time of the three concaves,and the hospitalization time were significantly shorter in the combined treatment group than in the treatment group(P<0.05).Conclusion Ambroxol combined with CPAP is superior to CPAP in the treatment of neonatal respiratory distress syndrome.