特发性血小板减少性紫癜患者巨核细胞和血小板参数的探讨

Analysis of Megakaryocytes and Platelet Parameters of ITP Patients

目的:探讨骨髓巨核细胞与外周血血小板参数的变化在特发性血小板减少性紫癜(ITP)鉴别诊断中的价值。方法:研究设ITP患者组(46例)、非ITP患者组(45例)和健康人对照组(48例),分别检测ITP和非ITP组患者骨髓中巨核细胞及外周血血小板参数及健康对照组外周血血小板参数;采用t检测进行统计学分析。结果:与非ITP组相比,ITP组患者骨髓中巨核细胞数量明显增加,其中颗粒巨、幼巨核细胞明显增加,产板巨核细胞明显减少,差异有统计学意义(P<0.01),而外周血血小板各参数2组间无差异(P>0.05)。ITP组和健康对照组相比,外周血小板数量和压积均明显降低,有统计学意义(P<0.01)。结论:骨髓巨核细胞数目、分类及外周血血小板各参数,对ITP的鉴别诊断具有一定的参考价值。

Objective: To investigate the value of bone marrow megakaryocyte( BMK) and peripheral platelet parameter changes in differential diagnosis of idiopathic thrombocytopenic purpura( ITP). Methods: The 91 patients were divided into 2 groups: ITP group( 46 cases) and non-ITP group( 45 cases),while 48 healthy volunteers were used as healthy controls. The parameters of BMK and peripheral platelets of ITP and non-ITP patients,and parameters of peripheral platelets of healthy controls were detected and compared. Results: As compared with non-ITP group,the BMK count in ITP group obviously increased,including the gramlar MK and proo-MK,while the MK producing platelets obviously dicreased with statistical difference( P < 0. 01); the platelet parameters in 2 groups did not show significant difference( P > 0. 05). As compared with healthy control group,the platelet level and PCT of peripheral blood in ITP group significantly decreased( P < 0. 01). Conclusion: The BMK level and platelet parameters,especially the platelet count and PCT have clinical value for differential diagnosis of ITP to a certain degree.