NF-κB介导的调节性T细胞的发育及其在移植物抗宿主病中的作用

Development of Regulatory T Cells Mediated by NF-kB and Its Role in GVHD——Review

移植物抗宿主病(GVHD)是异基因造血干细胞移植(allo-HSCT)后长期存活患者的主要并发症,也是导致移植后长期存活患者非复发相关死亡的主要原因。诸多研究表明,调节性T细胞(Treg)可以抑制早期GVHD。作为一种多效的转录因子,核因子-κB(NF-κB)可以调控Treg细胞的增殖和活化,从而成为防治GVHD的潜在靶点。现就NF-κB的功能、激活途径以及与GVHD的关系作一阐述。

Graft versus host disease(GVHD) is the major complication of allogenic hematopoietic stem cell transplantation(allo-HSCT),and is a mainly responsible result for the non-recurrence-related mortality of long-term survived patient after transplantation.Studies indicated that regulatory T(Treg) cells can inhibit early-GVHD.Since the transcriptional factor NF-κB has been implicated in the regulation of Treg cell proliferation and activation,it becomes a potential target of GVHD therapy.Thus,in this review the function and signaling pathway of NF-κB,as well as the relationship between GVHD and NF-κB,are discussed and summarized.