期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

膀胱移行细胞癌中血管内皮生长因子的表达及临床意义 被引量：4

Expression and clinical significance of Vascular Endothelial Cell Growth Factor(VEGF) in Transitional Cell Carcinoma of Bladder
下载PDF
导出
摘要 目的探讨血管内皮生长因子(VEGF)与膀胱移行细胞癌的关系。方法膀胱移行细胞癌组织制成病理切片后,采用SP二步法进行免疫组化染色,计算MVD、VEGF的表达。结果膀胱移行细胞癌患者中VEGF明显高于对照组,VEGF在不同的病理分级、分期中有不同的表达。膀胱移行细胞癌MVD高于对照组,且与膀胱癌的病理分级、分期有关。结论VEGF与膀胱癌的发生、发展及预后相关。 Objective To evaluate the relationship between vascular endothelial cell growth factor(VEGF) and transitional cell carcinoma of bladder(BTCC).Methods Detection of VEGF and MVD expression of VEGF and MVD were investigated by means of immunohistochemistry.Results The expression of VEGF in the bladder transitional cell carcinoma group was significantly higher than that of the control group.VEGF was closely related to tumor cell nuclear grade and clinical stage.MVD in BTCC was higher than that in controls and related to tumor cell nuclear grade and clinical stage.Conclusion VEGF is associated with the development and prognosis of Bladder Transitional Cell Carcinoma.
作者 王业华 俞俊杰
机构地区 扬州大学临床医学院泌尿外科
出处 《实用临床医药杂志》 CAS 2009年第8期39-41,共3页 Journal of Clinical Medicine in Practice
关键词 膀胱肿瘤 血管内皮生长因子 微血管密度 Bladder neoplasms VEGF MVD
分类号 R737.14 [医药卫生—肿瘤]
  • 相关文献

参考文献11

  • 1J. Kroll,J. Waltenberger.Regulation der Endothelfunktion und der Angiogenese durch den Vaskul?ren Endothelialen Wachstumsfaktor-A (VEGF-A)[J].Zeitschrift für Kardiologie.2000(3)
  • 2Teo NB,Shoker BS,Martin L,et al.Angiogenesis in pre-invasive cancers[].Anticancer Research.2002
  • 3Forster Y,Meye A,Krause S,et al.Antisense-mediated VEGF suppression in bladder and breast cancer cells[].Cancer Letters.2004
  • 4Veikkola T,Alitalo K.VEGFs, receptors and angiogenesis[].Seminars in Cancer Biology.1999
  • 5Kroll J,Waltenberger J.Regulation of the endothelial function and angiogenesis by vascular endothelial growth factor-A(VEGF-A)[].Zeitschrift fur Kardiologie.2000
  • 6Thaloor D,Singh AK,Sidhu GS,et al.Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcumin[].Cell Growth and Differentiation.1998
  • 7Gitay-Goren H,Halaban R,Neufeld G.Human melanoma cells but not normal melanocytes express vascular endothelial growth factor receptors[].Biochemical and Biophysical Research Communications.1993
  • 8Campbell S C,Volpert O V,Ivanovich M,et al.Molecular mediators of angiogenesis in bladder cancer[].Cancer Research.1998
  • 9Inoue K,Slaton JW,Davis DW,et al.Treatment of human metastatic transitional cell carcinoma of the bladder in a murine model with the anti-vascular endothelial growth factor receptor monoclonal antibody DC101 and paclitaxel[].Clinical Cancer Research.2000
  • 10Aguayo A,Estey E,Kantarjian H,et al.Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia[].Blood.1999

同被引文献37

  • 1沈肖曹,杜传军,史时芳,陈继民,经宵.经尿道钬激光切除与经尿道电切治疗浅表性膀胱肿瘤的疗效比较[J].中华泌尿外科杂志,2005,26(1):30-32. 被引量：42
  • 2夏术阶,孙晓文,朱江,鲁军,凡杰,朱轶勇.经尿道钬激光局部膀胱壁切除治疗肌层浸润膀胱肿瘤[J].中华泌尿外科杂志,2005,26(5):352-352. 被引量：27
  • 3申桂华,姜展红.卵巢肿瘤的血管内皮生长因子表达和肿瘤微血管密度计数的意义[J].中国临床保健杂志,2006,9(1):4-6. 被引量：3
  • 4Moh M C,Lee L H ,Shen S. Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma[ J]. J Hepatol,2005,42(6 ) :833- 841.
  • 5Sobin D H, Witteking C. TNM classification of malignant turnouts [ M ]. 6th ed. New York : Wiley-Liss,2002 : 199-202.
  • 6Helpap B. New WHO classification of urothelial carcinoma of the urinary bladder [ J ]. Verb Dtsch Ges pathol,2002,86:57- 66.
  • 7Mob M C,Lee L H,Yang X,et al. HEPNI ,a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis HepG2 cells [ J ]. J Hepatol, 2003,39(4) :580-586.
  • 8Mob M C ,Zhang C ,Luo C ,et al. Structural and functional analyses of a novel ig-like cell adhesion molecule, hepaCAM,in the human breast carcinoma MCF7 cells [ J]. J Biol Chem, 2005,280 ( 29 ) : 27366-27374.
  • 9Masuda M, Yageta M, Fukuhara H,et al. The tumor suppressor protein TSLC1 is involved in cell-cell adhesion [ J ]. J Biol Chem, 2002,277 (34) :31014-31019.
  • 10Krushel L A,Tai M H,Cunningham B A,et al. Neural cell adhesion molecule (N-CAM)domains and intracellular signaling pathways involved in the inhibition of astrocyte proliferation [ J ]. Pro Natl Acad Sci USA ,1998,95 (5) :2592-2596.

引证文献4

二级引证文献8

实用临床医药杂志
2009年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部