急性冠状动脉综合征患者血清hs-CRP与颈动脉粥样硬化的相关性研究

Research on the relevance between hs-CRP and carotid atherosclerosis in the patients with acute coronary syndrome

目的探讨急性冠状动脉综合征(ACS)患者颈动脉粥样硬化与血清超敏-C反应蛋白(hs-CRP)的相关性。方法对本院80例ACS患者和健康体检者86例均进行颈动脉超声检查,测量颈动脉内膜中层厚度(IMT),观察有无颈动脉斑块形成及斑块的性质,同时进行血清hs-CRP浓度的测定。结果两组hs-CRP浓度间差异有显著性意义(P<0.05)。ACS组中正常8例,增厚15例,生成斑块57例,3组患者hs-CRP间差异有非常显著性意义(P<0.01),且两两比较各组患者hs-CRP水平间差异亦均有非常显著性意义(P<0.01)。颈动脉斑块生成者中稳定斑块者与不稳定斑块者hs-CRP间差异亦有非常显著性意义(P<0.01)。结论血清hs-CRP与急性冠状动脉综合征患者颈动脉粥样硬化的发生有一定相关性,炎症反应可能参与了急性冠状动脉综合征颈动脉粥样硬化的形成。

Objective To investigate the relevance between serum high-sensitivity-C(hs-CRP) and carotid atherosclerosis in the patients with acute coronary syndrome.Methods 80 cases of acute cerebralinfarction patients and healthy persons were examined by carotid artery ultrasound to measure carotid intima-media thickness(IMT),and to observe whether the carotid artery plaque formated and the nature of plaque.At the same time,serum concentrations were measured.Results Significant difference of hs-CRP concentration(P<0.05) was found in normal subjects.In ACS group,there are 8 normal cases,15 thickened cases,and 57 cases of plaques,and there was significant difference in hs-CRP among them(P<0.01).Moreover,there was significant difference in hs-CRP levels between stable and unstable plaques in patients with carotid artery plaques(P<0.01).Conclusion There is relevance between the serum hs-CRP and the formation of carotid atherosclerosis in patients with acute coronary syndrome,and inflammatory response may be involved in the formation of carotid atherosclerosis in patients with acute coronary syndrome.