要重视急性舒张性心力衰竭的防治

Pay Attention To The Prevention And Treatment Of The Acute Diastolic Heart Failure

舒张性心力衰竭是常发生在危重症患者的急性心力衰竭,包括高血压危象、心律失常、心肌缺血和脓毒血症常常引起急性舒张性心力衰竭。其特征是左室舒张功能受损、左室硬度增加、间质胶原增加及细胞外基质蛋白修饰。氧化应激和炎症反应可能是舒张性心力衰竭的发生机制。肾素-血管紧张素-醛固酮轴阻滞剂、一氧化氮制剂及特异针对肌动蛋白-肌球蛋白横桥产生的新药治疗有效。

Diastolic heart failure is common in critically ill patients who suffered from hypertensive crisis,arrhythmia,myocardial ischemia and sepsis.Diastolic heart failure is characterized by impaired left ventricular diastolic function,increased left ventricular stiffness,increased interstitial collagen and extracellular matrix protein modification.Oxidative stress and inflammation may be the mechanism of diastolic heart failure.Inhibitors of the renin-angiotensin-aldosterone system,nitric oxide preparation and specific drugs for actin and myosin cross bridge are effective.