高血压致舒张性心力衰竭的发生机制及处理

Mechanisms and Management of Diastolic Heart Failure Induced by Hypertension

95%难治性高血压和72%可控制的高血压患者存在左室舒张功能不全。高血压左室肥大时,心肌细胞肥大同时伴有心肌微循环减少、间质纤维化、细胞凋亡增加和左室刚度增加。动脉硬化和左室刚度间互动耦合在左室射血分数降低的心衰和左室射血分数正常的心衰发生发展中起到特别重要的作用。

There were 95%refractory hypertension and 72%controlled hypertension patients who had left ventricular diastolic dysfunction.When patients suffered from left ventricular hypertrophy induced by hypertension,there was myocardial cell hypertrophy as well as the decreased myocardial microcirculation,interstitial fibrosis,increased cell apoptosis,and increased left ventricular stiffness.It is the coupling interaction between arterial stiffness and left ventricular stiffness that played a particularly important role in the development of heart failure in the patients whose left ventricular ejection fraction were reduced or normal.