老年慢性心力衰竭患者抗心力衰竭治疗后血浆脑利钠肽水平分布及影响因素分析

Distribution of Plasma Brain Natriuretic Peptide in Elderly Patients with Chronic Heart Failure after Anti-heart Failure Treatment and Its Influencing Factors

目的分析老年慢性心力衰竭患者经抗心力衰竭治疗以后患者的血浆脑利钠肽(BNP)水平和相关影响因素。方法本研究所选择的研究对象来自我院在2014年10月至2016年12月贵州省肿瘤医院收治的老年慢性心力衰竭患者45例,对所有患者临床资料进行回顾性分析,并将患者设为观察组,同时选择我院同期体检的45例健康人群作为本研究的对照组,对两组研究对象的收缩压、舒张压、肺淤血、肺动脉高压、左室射血分数等情况进行比较,同时对于相关结果的影响因素进行分析。对观察组患者经过抗心力衰竭治疗之前和治疗之后的BNP水平进行比较,并且对患者抗心力衰竭治疗效果进行评估。结果本研究两组研究对象,的收缩压、舒张压、肺淤血、肺动脉高压、左室射血分数等情况比较差异均有统计学意义(P<0.05);对观察组患者治疗前后的BNP水平进行比较,治疗前后差异有统计学意义(P<0.05)。结论低血压、肺淤血等相关因素是慢性心力衰竭当中的独立危险因素,通过抗心力衰竭治疗以后,患者的BNP水平能够得到明显的改善。

Objective To analyze the level of plasma brain natriuretic peptide( BNP) and the related factors in the patients with chronic heart failure after anti heart failure treatment. Methods The subjects selected from our hospital in 45 cases of elderly patients with chronic heart failure from October 2014 to December 2016 in Guizhou Cancer Hospital,the clinical data of all patients were analyzed retrospectively,and the patients as the observation group,and 45 healthy persons in our hospital were selected as control group in this study. Two groups of subjects of systolic blood pressure,diastolic blood pressure,pulmonary congestion,pulmonary hypertension,compare the left ventricular ejection fraction,and affecting factors of the related results were analyzed. Comparison of the patients in the observation group before after anti heart failure treatment and treatment level of BNP patients,and to assess the resistance the treatment of heart failure. Results There were significant differences in systolic blood pressure,diastolic blood pressure,pulmonary congestion,pulmonary hypertension and left ventricular ejection fraction between the two groups( P < 0. 05). The levels of BNP in the observation group were compared before and after treatment,and the difference was statistically significant before and after treatment( P < 0. 05). Conclusion Hypotension,pulmonary congestion and other related factors are independent risk factors of chronic heart failure. After the treatment of anti heart failure,the BNP level of patients can be significantly improved.