冠心病患者血清补体C3、C4及HDL-C水平分析

The levels of serum complement C3,C4 and HDL-C in patients with coronary heart disease

目的分析冠心病(CHD)患者血清补体C3、C4与HDL-C的水平。方法依据病情将2016年5月至2017年10月西安市第五医院收治的137例CHD患者分为急性冠脉综合征组(ACS组,80例)和稳定性冠心病组(SCHD组,57例),选取同时期健康体检的60例健康人员纳为对照组。对比3组患者补体C3、C4、HDL-C水平,分析补体C3、C4水平与HDL-C水平的相关性。结果 ACS组和SCHD组患者补体C3水平均高于对照组(P <0. 05); ACS组患者补体C3水平高于SCHD组(P <0. 05);ACS组患者补体C4水平高于对照组(P <0. 05),SCHD组患者补体C4水平低于对照组(P <0. 05);对照组HDL-C水平高于ACS组和SCHD组患者(P <0. 05)。ACS组和SCHD组患者血清补体C3、C4水平与HDL-C水平无关(P> 0. 05),对照组血清补体C3水平与HDL-C水平呈负相关(P <0. 05)。结论 CHD患者血清补体C3、C4水平升高,HDL-C水平降低,炎症反应影响血清补体与HDL-C水平的相关性。

Objective To analyze the levels of serum complement C3,C4 and HDL-C in patients with coronary atherosclerotic heart disease( CHD). Methods A total of 137 patients with CHD admitted to Xi’an No. 5 Hospital from May of 2016 to October of 2017 were divided into acute coronary syndrome group( ACS group,80 cases) and stable coronary heart disease group( SCHD group,57 cases). Sixty healthy persons in the same period were selected as the control group. The levels of complement C3,C4 and HDL-C were compared among the 3 groups,and the correlation between complement C3,C4 levels and HDL-C level was analyzed. Results The level of complement C3 in ACS group and SCHD group was higher than that in control group( P < 0. 05);the level of complement C3 in ACS group was higher than that in SCHD group( P < 0. 05);the level of complement C4 in ACS group was higher than that in control group( P < 0. 05);the level of complement C4 in SCHD group was lower than that in control group( P < 0. 05);the level of HDL-C in control group was higher than that in ACS group and SCHD group( P < 0. 05). Serum complement C3 and C4 levels in ACS group and SCHD group were not correlated with HDL-C levels( P > 0. 05),while serum complement C3 levels in control group were negatively correlated with HDL-C levels( P < 0. 05).Conclusion The levels of serum complement C3 and C4 increased and HDL-C decreased in CHD patients.Inflammation affected the correlation between serum complement and HDL-C levels.