左卡尼汀联合卡托普利对扩张型心肌病合并心力衰竭的疗效观察

Effect of levocarnitine combined with captopril in the treatment of dilated cardiomyopathy complicated with heart failure

目的研究左卡尼汀联合卡托普利治疗扩张型心肌病合并心力衰竭的临床效果。方法选取2016年4月至2017年12月胶州市人民医院收治的92例扩张型心肌病合并心力衰竭患者,依照治疗方案分为对照组和观察组,各46例。两组均接受常规抗心衰治疗,对照组接受左卡尼汀注射液治疗,观察组接受左卡尼汀注射液联合卡托普利治疗。比较两组治疗前后左心室射血分数(LVEF),左心室收缩末期内径(LVESD),血清脑钠肽(BNP)、转化因子β1 (TGF-β1)水平及MLHFQ评分。结果治疗后观察组LVEF大于对照组,LVESD小于对照组(P <0. 05);治疗后观察组血清BNP水平低于对照组,血清TGF-β1水平高于对照组(P <0. 05);治疗后观察组MLHFQ评分低于对照组(P <0. 05)。结论左卡尼汀注射液联合卡托普利治疗扩张型心肌病合并心力衰竭,能有效改善患者心功能,降低血清BNP水平,提高TGF-β1水平,提升其生活质量。

Objective To study the effect of levocarnitine combined with captopril in the treatment of dilated cardiomyopathy complicated with heart failure. Methods A total of 92 patients with dilated cardiomyopathy complicated with heart failure treated in Jiaozhou People ’s Hospital from April of 2016 to December of 2017 were selected and divided into control group and observation group according to the treatment plans,46 cases in each group. Both groups received routine anti-heart failure treatment. The control group received levocarnitine injection treatment,and the observation group received levocarnitine injection combined with captopril treatment. Left ventricular ejection fraction( LVEF),left ventricular end-systolic diameter( LVESD),serum brain natriuretic peptide( BNP),transforming factor-β1( TGF-β1) levels and MLHFQ scores were compared between the two groups before and after treatment. Results After treatment,the LVEF of the observation group was higher than that of the control group,and the LVESD of the observation group was lower than that of the control group( P < 0. 05). After treatment,the serum BNP level of the observation group was lower than that of the control group,and the serum TGF-β1 level was higher than that of the control group( P < 0. 05). After treatment,the MLHFQ score of the observation group was lower than that of the control group( P < 0. 05). Conclusion In the treatment of dilated cardiomyopathy complicated with heart failure,levocarnitine injection combined with captopril can effectively improve cardiac function,reduce serum BNP level,improve the level of TGF-β1,and improve the quality of life of patients with dilated cardiomyopathy