阿托品拮抗DHE减慢心率和抑制呼吸的作用

Antagonist Effects of Atropine on Dihydroetorphine in Inhibiting Heart Rate and Respiration

静脉注射DHE0.5μS/kg引起兔呼吸抑制和心率减慢。侧脑室注射阿托品0.1mg/kg使兔呼吸加快和心率减慢,两药合用,阿托品可拮抗DHE呼吸抑制作用,但不能拮抗其心率减慢。静脉注射阿托晶1mg/kg可拮抗DHE所致之心率减慢,亦可拮抗其呼吸抑制,但作用发生较慢。

In rabbits, after dihydroetorphine ( DHE ) 0.5 μg/kg iv, respiration was inhibited and heart rate was decreased. Atropine 0.lmg/kg icv stimulated respiration and slowed heart rate. When DHE was combined with atropine(0.05-0.1 mg/kg icv) , the inhibition of respiration was abolished but the slow heart rate persisted. However, intravenous atropine 1 mg/kg antagonized the inhibiting effect of DHE on heart as well as on respiration, though the effect was rather slow.