双龙丸对稳定性心绞痛患者颈动脉内中膜厚度的影响

Effect of Shuanglong Pill on Carotid Intimal-Media Thickness in Stable Angina Pectoris

为观察双龙丸对颈动脉内中膜厚度 (IMT)的影响 ,将 13 1例诊断为冠心病稳定性心绞痛患者分为两组 :双龙丸组 ( 82例 )服用双龙丸 1 5克 /次 ,每日 3次 ,治疗 6月 ;开搏通组 ( 4 9例 )服用开搏通 12 5mg/次 ,每日 2次 ,治疗 6月。观察患者血压、心率 ,2 4小时动态心电图 ,颈动脉IMT和斑块面积变化。结果 :两组均非常显著性降低收缩压、舒张压和心率 (P <0 0 1)。两组治疗前后ST↓max有非常显著性差异 (P <0 0 1) ,ST↓ >1mm时间有显著性降低 (P <0 0 5 ) ;双龙丸组ST↓ >1mm的次数有显著性差异 (P <0 0 5 ) ,两组ST↓max和ST↓ >1mm时间比较有显著性差异 (P <0 0 5 )。两组治疗前后IMT均有非常显著性改变 (P <0 0 1) ,两组间比较无显著性差异。两组治疗前后斑块面积均无显著性改变。提示双龙丸可能通过改善颈动脉内中膜厚度延缓动脉粥样硬化 (AS)

To observe the effect of Shuanglong pill on the carotid intima-media thickness(IMT),131 patients with stable angina pectoris were randomized into treatment group in which 82 cases were treated with the Pill,1.5g each time and three times daily,and control group in which 49 cases were treated with captopril,12.5mg each time and twice daily,both with a course of 6 months.Blood pressure,heart rate,ambulatory electrocardiogram,carotid IMT and plaque area were detected.Results:There was a very significant decrease in systolic and diastolic pressure,heart rate in both groups (P<0.01);there were significant differences in ST↓max(P<0.01)and ST↓>1mm(P<0.05)between pretreatment and post-treatment in both groups;there were more significant decrease in ST↓ max and duration of ST↓>1 mm in treatment group than in control group,and very significant decease in carotid IMT(P<0.01)in both groups;there was no difference in plaque area between two groups.It is showed that Shuanglong pill can delay the process of AS by improving carotid IMT.